Leptophos

Base Information Edit

Chemical Name:Leptophos
CAS No.:21609-90-5
Deprecated CAS:73270-49-2
Molecular Formula:C13H10 Br Cl2 O2 P S
Molecular Weight:412.071
Hs Code.:2930909090
European Community (EC) Number:244-472-8
UN Number:3464,3018
UNII:C45E8FUG3Z
DSSTox Substance ID:DTXSID3040279
Nikkaji Number:J3.791E
Wikipedia:Leptophos
Wikidata:Q6528275
Metabolomics Workbench ID:45110
ChEMBL ID:CHEMBL2074801
Mol file:21609-90-5.mol

Synonyms:Leptophos;Phosvel

Suppliers and Price of Leptophos

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Leptophos
250mg
$ 245.00

Tocris
LeptomycinB
5U
$ 367.00

Sigma-Aldrich
Leptophos PESTANAL
100mg
$ 101.00

AHH
Leptophos 98%
1g
$ 342.00

Total 0 raw suppliers

Chemical Property of Leptophos Edit

Chemical Property:

Vapor Pressure:1.12E-07mmHg at 25°C
Melting Point:71-73 °C
Refractive Index:1.651
Boiling Point:444.4 °C at 760 mmHg
Flash Point:222.6 °C
PSA：60.36000
Density:1.66 g/cm³
LogP:6.06670
Storage Temp.:0-6°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:0.005 mg l-1
XLogP3:6.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:409.86996
Heavy Atom Count:20
Complexity:368
Transport DOT Label:Poison

Purity/Quality:: Leptophos ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T,N,Xi
Statements: 21-25-39/25-50/53-36/37/38
Safety Statements: 25-36/37/39-45-60-61-23-36-26

MSDS Files:

Useful:

Chemical Classes:Pesticides -> Organophosphate Insecticides
Canonical SMILES:COP(=S)(C1=CC=CC=C1)OC2=CC(=C(C=C2Cl)Br)Cl
Uses Insecticide. Leptomycin B is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. It covalently binds to cysteine residue in the center of CRM1/exportin 1 protein.

Technology Process of Leptophos

There total 9 articles about Leptophos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 21609-90-5
leptophos

Guidance literature:: Multi-step reaction with 2 steps

1: 40percent aq. NaOH / benzyltriethylammonium chloride / benzene / 0.75 h / Ambient temperature

2: K₂CO₃ / benzyltriethylammonium chloride / benzene / 3 h / Heating

With sodium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In benzene;

Reference yield:

: 3497-00-5
phenylthiophosphonic acid dichloride

: 21609-90-5
leptophos

Guidance literature:: Multi-step reaction with 2 steps

1: 40percent aq. NaOH / benzyltriethylammonium chloride / benzene / 0.75 h / Ambient temperature

2: K₂CO₃ / benzyltriethylammonium chloride / benzene / 3 h / Heating

With sodium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In benzene;