Verapamil

Base Information Edit

Chemical Name:Verapamil
CAS No.:52-53-9
Deprecated CAS:56949-77-0,7482-85-1,1007128-78-0
Molecular Formula:C27H38N2O4
Molecular Weight:454.61
Hs Code.:
European Community (EC) Number:200-145-1
UNII:CJ0O37KU29
DSSTox Substance ID:DTXSID9041152
Nikkaji Number:J4.132G,J332.327G
Wikipedia:Verapamil
Wikidata:Q410291
NCI Thesaurus Code:C928
RXCUI:11170
Pharos Ligand ID:C4B57RM89FV7
Metabolomics Workbench ID:37889
ChEMBL ID:CHEMBL6966
Mol file:52-53-9.mol

Synonyms:Calan;Cordilox;Dexverapamil;Falicard;Finoptin;Hydrochloride, Verapamil;Iproveratril;Isoptin;Isoptine;Izoptin;Lekoptin;Verapamil;Verapamil Hydrochloride

Suppliers and Price of Verapamil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Verapamil 98.82%
50mg
$ 85.00

American Custom Chemicals Corporation
VERAPAMIL 95.00%
100G
$ 43100.00

AK Scientific
Verapamil
5g
$ 851.00

AHH
Verapamil 98%
1g
$ 310.00

Activate Scientific
Verapamil 98%
250 mg
$ 191.00

Total 65 raw suppliers

Chemical Property of Verapamil Edit

Chemical Property:

Appearance/Colour:Viscous, pale yellow oil.
Melting Point:25°C
Refractive Index:1.5448
Boiling Point:586.1 °C at 760 mmHg
PKA:8.6(at 25℃)
Flash Point:308.3 °C
PSA：63.95000
Density:1.058 g/cm³
LogP:5.09308
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:454.28315770
Heavy Atom Count:33
Complexity:606

Purity/Quality:

99% ^*data from raw suppliers

Verapamil 98.82% ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Cardiovascular Agents
Canonical SMILES:CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
Recent ClinicalTrials:The Intra-arterial Vasospasm Trial
Recent EU Clinical Trials:Quinidine versus verapamil in short-coupled idiopathic ventricular fibrillation: An open label, randomized crossover pilot trial
Recent NIPH Clinical Trials:Comparison of plasma concentrations of verapamil in healthy adults using simple suspension
Uses Vasodilator (coronary). Verapamil is primarily used as an antiarrythmic for treating ventricular arrhythmias; however, currently it is being forced out gradually by adenosine. Verapamil is used for preventing angina pectoris attacks, arterial hypertension, and treating and preventing supraventricular arrhythmia (paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, extrasystole).
Clinical Use Verapamil (Isoptin, Covera), in addition to its use as an antiarrhythmic agent, has been employed extensively in the management of variant (Prinzmetal’s) angina and effort-induced angina pectoris. It selectively inhibits the voltage-gated calcium channel that is vital for action potential genesis in slowresponse myocytes, such as those found in the sinoatrial and A-V nodes. Verapamil is useful for slowing the ventricular response to atrial tachyarrhythmias, such as atrial flutter and fibrillation. Verapamil is also effective in arrhythmias supported by enhanced automaticity, such as ectopic atrial tachycardia and idiopathic left ventricular tachycardia.

Technology Process of Verapamil

There total 7 articles about Verapamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%