Quinolin-8-yl dihydrogen phosphate

Base Information

• Chemical Name: Quinolin-8-yl dihydrogen phosphate
• CAS No.: 7220-39-5
• Molecular Formula: C₉H₈NO₄P
• Molecular Weight: 225.141
• DSSTox Substance ID: DTXSID40980099
• Nikkaji Number: J1.418.240C
• Mol file: 7220-39-5.mol

Synonyms:quinolin-8-yl dihydrogen phosphate;7220-39-5;8-Quinolinol, dihydrogen phosphate (ester);SCHEMBL4461219;DTXSID40980099

Chemical Property of Quinolin-8-yl dihydrogen phosphate

Chemical Property:

• Vapor Pressure: 1.25E-09mmHg at 25°C
• Boiling Point: 469.8°C at 760 mmHg
• Flash Point: 237.9°C
• PSA: 89.46000
• Density: 1.569g/cm³
• LogP: 1.70630
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 225.01909473
• Heavy Atom Count: 15
• Complexity: 267

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)OP(=O)(O)O)N=CC=C2

Technology Process of Quinolin-8-yl dihydrogen phosphate

There total 2 articles about Quinolin-8-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → 8-Chinolylphosphat (7220-39-5)

Guidance literature:

8-quinolinol; With dmap; t-butylphosphite bound on the Wang resin A; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 23 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;

DOI:10.1016/S0960-894X(02)00140-3

Reference yield:

→ 8-Chinolylphosphat (7220-39-5)

Guidance literature:

8-Hydroxychinolin, Phosphorylchlorid;

DOI:10.1248/cpb.25.2121

upstream raw materials:

8-quinolinol

Refernces

• 1、 Deprez, Pierre,Mandine, Eliane,Gofflo, Dominique,Meunier, Stephane,Lesuisse, Dominique. "Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein". . p. 1295 - 1298. Retrieved 2007/10/03.