1,8-Diamino-3,6-dioxaoctane

Base Information

• Chemical Name: 1,8-Diamino-3,6-dioxaoctane
• CAS No.: 929-59-9
• Molecular Formula: C6H16N2O2
• Molecular Weight: 148.205
• Hs Code.: 29221990
• European Community (EC) Number: 213-203-6,868-781-8
• NSC Number: 28972
• UNII: R41ZT4UF34
• DSSTox Substance ID: DTXSID9044742
• Nikkaji Number: J35.180F
• Wikidata: Q27287770
• ChEMBL ID: CHEMBL3186348
• Mol file: 929-59-9.mol

Synonyms:bis(polyoxyethylene bis(amine));PEGA polymer

Chemical Property of 1,8-Diamino-3,6-dioxaoctane

Chemical Property:

• Appearance/Colour: CLEAR COLOURLESS LIQUID
• Vapor Pressure: 0.0369mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Boiling Point: 241 °C at 760 mmHg
• PKA: 9.04±0.10(Predicted)
• Flash Point: 104.3 °C
• PSA: 70.50000
• Density: 1.015g/cm³
• LogP: 0.33760
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in 0.4 parts water.
• XLogP3: -2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 148.121177757
• Heavy Atom Count: 10
• Complexity: 53.7

Purity/Quality:

98% ^*data from raw suppliers

1,8-Diaminotriethyleneglycol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34-42/43-37
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C(COCCOCCN)N
• Description: Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
• Uses: 2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.

Technology Process of 1,8-Diamino-3,6-dioxaoctane

There total 14 articles about 1,8-Diamino-3,6-dioxaoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2)

Guidance literature:

Reference yield: 90.0%

tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate (153086-78-3) → 3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2)

Guidance literature:

With methanol; oxalyl dichloride; at 20 ℃; for 2h;

DOI:10.1039/d0ra04110f

Reference yield: 88.8%

1,8-diphthalimido-3,6-dioxaoctane (31255-11-5) → 3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

DOI:10.1021/jo00328a015

upstream raw materials:

1,8-diphthalimido-3,6-dioxaoctane

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

1,2-bis(2-chloroethoxy)ethane

1,8-diazido-3,6-dioxaoctane

Downstream raw materials:

1,14-Dioxa-4,6,9,11-tetraaza-cyclohexadecane-5,10-dithione

C₃₈H₄₀N₆O₆

(2R,4aR,6S,6aR,22aS,22bR)-6-Methoxy-2-phenyl-dodecahydro-1,3,5,7,13,16,22-heptaoxa-10,19-diaza-cyclooctadeca[a]naphthalene-9,20-dione

18-Benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-2,6,17-trione

Refernces

• 1、 -. "Method for preparing 1, 8 -diamino -3 and 6 -dioxaoctane through hydrogenation of triethylene glycol". Paragraph 0024-0039. . Retrieved 2021/09/08.
• 2、 Akine, Shigehisa,Onuma, Takahiro,Nabeshima, Tatsuya. "A novel graphite-like stacking structure in a discrete molecule and its molecular recognition behavior". supporting information. p. 9369 - 9372. Retrieved 2018/06/18.