1,4-Dimethoxy-2,5-dimethylbenzene

Base Information

• Chemical Name: 1,4-Dimethoxy-2,5-dimethylbenzene
• CAS No.: 2674-32-0
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• NSC Number: 168507
• DSSTox Substance ID: DTXSID00304959
• Nikkaji Number: J433.465E
• Wikidata: Q82051325
• Mol file: 2674-32-0.mol

Synonyms:1,4-dimethoxy-2,5-dimethylbenzene;2674-32-0;NSC168507;2,5-dimethox y-p-xylene;SCHEMBL2954181;DTXSID00304959;GTAGBLIBQSOQHG-UHFFFAOYSA-N;2,5-dimethoxy-1,4-dimethylbenzene;AKOS006294670;NSC-168507;benzene, 1,4-dimethoxy-2,5-dimethyl-;AB-131/42300996;InChI=1/C10H14O2/c1-7-5-10(12-4)8(2)6-9(7)11-3/h5-6H,1-4H

Chemical Property of 1,4-Dimethoxy-2,5-dimethylbenzene

Chemical Property:

• Vapor Pressure: 0.0576mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 240.8 °C at 760 mmHg
• Flash Point: 88.6 °C
• PSA: 18.46000
• Density: 0.977 g/cm³
• LogP: 2.32060
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 120

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dimethoxy-2,5-dimethylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)C)OC

Technology Process of 1,4-Dimethoxy-2,5-dimethylbenzene

There total 9 articles about 1,4-Dimethoxy-2,5-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,5-dimethylhydroquinone (615-90-7) + methyl iodide (74-88-4) → 1,4-dimethoxy-2,5-dimethylbenzene (2674-32-0)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1002/ejoc.200700885

Reference yield: 89.0%

2,5-dimethylhydroquinone (615-90-7) + dimethyl sulfate (77-78-1) → 1,4-dimethoxy-2,5-dimethylbenzene (2674-32-0)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1002/ejoc.201701124

Reference yield: 88.0%

2,5-Dimethyl-1,4-benzoquinone (137-18-8) + dimethyl sulfate (77-78-1) → 1,4-dimethoxy-2,5-dimethylbenzene (2674-32-0)

Guidance literature:

2,5-Dimethyl-1,4-benzoquinone; With sodium tetrahydroborate; In ethanol; water; at 20 ℃; for 0.5h; Inert atmosphere;

With potassium hydroxide; In ethanol; water; for 0.5h; Inert atmosphere; Reflux;

dimethyl sulfate; In ethanol; water; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.electacta.2019.135580

upstream raw materials:

diethyl sulfate

3-bromo-1,4-dimethoxy-2,5-dimethylbenzene

2,5-dimethylhydroquinone

dimethyl sulfate

Downstream raw materials:

1-Chloro-2,5-dimethoxy-3,6-dimethylbenzene

2,5-dichloroxyloquinone

1,4-dimethoxy-2,5-dimethyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)benzene

Refernces

• 1、 Stahlhofen, Jana Marie,Schollmeyer, Dieter,Waldvogel, Siegfried R.. "One-Pot Synthesis to Quinone-Based Diaza[3.3]cyclophanes". . p. 7226 - 7230. Retrieved 2017/10/18.
• 2、 He, Li,Galland, Stephanie,Dufour, Claire,Chen, Guo-Rong,Dangles, Olivier,Fenet, Bernard,Praly, Jean-Pierre. "C-D-glucopyranosyl derivatives of tocopherols - Synthesis and evaluation as amphiphilic antioxidants". experimental part. p. 1869 - 1883. Retrieved 2009/04/04.