3-Chloro-6-isopropylpyridazine

Base Information

• Chemical Name: 3-Chloro-6-isopropylpyridazine
• CAS No.: 570416-35-2
• Molecular Formula: C7H9ClN2
• Molecular Weight: 156.615
• Hs Code.: 2933990090
• European Community (EC) Number: 839-098-2
• DSSTox Substance ID: DTXSID00591064
• Wikidata: Q72452834
• Mol file: 570416-35-2.mol

Synonyms:3-chloro-6-isopropylpyridazine;570416-35-2;3-chloro-6-propan-2-ylpyridazine;MFCD12143153;3-CHLORO-6-(PROPAN-2-YL)PYRIDAZINE;Pyridazine, 3-chloro-6-(1-methylethyl)-;SCHEMBL2600116;DTXSID00591064;UYKSBKJSQWGYTQ-UHFFFAOYSA-N;AKOS009606920;MB11649;AS-37493;SY105614;DB-240987;CS-0171940;EN300-179890;A853525;Z432063460

Chemical Property of 3-Chloro-6-isopropylpyridazine

Chemical Property:

• Boiling Point: 263 oC
• Flash Point: 138 oC
• PSA: 25.78000
• Density: 1.135
• LogP: 2.25340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 156.0454260
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

≥95% ^*data from raw suppliers

3-Chloro-6-isopropylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=NN=C(C=C1)Cl

Technology Process of 3-Chloro-6-isopropylpyridazine

There total 3 articles about 3-Chloro-6-isopropylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.8%

6-isopropylpyridazin-3(2H)-one (570416-36-3) → 3-chloro-6-isopropylpyridazine (570416-35-2)

Guidance literature:

6-isopropylpyridazin-3(2H)-one; With trichlorophosphate; for 1h; Heating / reflux;

With sodium hydroxide; In water; pH=6;

Reference yield:

3-chloro-6-(prop-1-en-2-yl)pyridazine → 3-chloro-6-isopropylpyridazine (570416-35-2)

Guidance literature:

With Wilkinson's catalyst; hydrogen; In methanol; at 20 ℃; under 775.743 Torr;

Reference yield:

→ 3-chloro-6-isopropylpyridazine (570416-35-2)

Guidance literature:

upstream raw materials:

6-isopropylpyridazin-3(2H)-one

Downstream raw materials:

6-isopropylpyridazin-3-amine

Refernces

• 1、 -. "HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 69. . Retrieved 2015/11/09.
• 2、 -. "COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY". Page/Page column 96. . Retrieved 2008/12/08.