2,4-Dichloro-n-hydroxybenzamide

Base Information

• Chemical Name: 2,4-Dichloro-n-hydroxybenzamide
• CAS No.: 2593-23-9
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• NSC Number: 9922
• DSSTox Substance ID: DTXSID90948846
• Nikkaji Number: J480.444I
• Wikidata: Q82926674
• ChEMBL ID: CHEMBL2436413
• Mol file: 2593-23-9.mol

Synonyms:2593-23-9;2,4-dichloro-n-hydroxybenzamide;2,4-dichlorobenzohydroxamic acid;NSC9922;2,4-dichlorobenzenecarbohydroxamic acid;SCHEMBL6790469;2,4-Dichlorobenzhydroximic acid;CHEMBL2436413;DTXSID90948846;2,4-dichlorobenzo hydroxamic acid;NSC-9922;AKOS000188037;2,4-Dichloro-N-hydroxybenzene-1-carboximidic acid

Chemical Property of 2,4-Dichloro-n-hydroxybenzamide

Chemical Property:

• Refractive Index: 1.607
• Density: 1.529 g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 204.9697338
• Heavy Atom Count: 12
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)C(=O)NO

Technology Process of 2,4-Dichloro-n-hydroxybenzamide

There total 4 articles about 2,4-Dichloro-n-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,4 dichlorobenzoic acid (50-84-0) → 2,4-dichlorobenzohydroxamic acid (2593-23-9)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 0 - 20 ℃; for 20.5h;

DOI:10.1016/j.bmcl.2013.08.081

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → 2,4-dichlorobenzohydroxamic acid (2593-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole-6-sulfonamidomethyl polystyrene resin; 1,3-diisopropylcarbodiimide; DMAP / dimethylformamide; CH₂Cl₂ / 3 h

1.2: tetrahydrofuran / 5 h

2.1: aq. TFA / 15 h

With dmap; 1-hydroxybenzotriazole-6-sulfonamidomethyl polystyrene resin; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b211526c

Reference yield:

C13H19Cl2NO2Si → 2,4-dichlorobenzohydroxamic acid (2593-23-9)

Guidance literature:

With trifluoroacetic acid; for 15h;

DOI:10.1039/b211526c

upstream raw materials:

2,4 dichlorobenzoic acid

Refernces

• 1、 Devocelle, Marc,McLoughlin, Brian M.,Sharkey, Caroline T.,Fitzgerald, Desmond J.,Nolan, Kevin B.. "A convenient parallel synthesis of low molecular weight hydroxamic acids using polymer-supported 1-hydroxybenzotriazole". . p. 850 - 853. Retrieved 2007/10/03.