N-(2-HYDROXYETHYL)SUCCINIMIDE

Base Information

• Chemical Name: N-(2-HYDROXYETHYL)SUCCINIMIDE
• CAS No.: 18190-44-8
• Molecular Formula: C6H9NO3
• Molecular Weight: 143.142
• Hs Code.: 2925190090
• Mol file: 18190-44-8.mol

Synonyms:Succinimide,N-(2-hydroxyethyl)- (6CI,7CI,8CI);1-(2-Hydroxyethyl)-pyrrolidine-2,5-dione;1-(2-Hydroxyethyl)pyrrolidin-2,5-dione;2-(2,5-Dioxopyrrolidin-1-yl)ethanol;N-(2-Hydroxyethyl)succinimide;N-(Hydroxyethyl)succinimide;NSC 38747;NSC50940;

Chemical Property of N-(2-HYDROXYETHYL)SUCCINIMIDE

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 2.36E-06mmHg at 25°C
• Melting Point: 57-61 °C(lit.)
• Refractive Index: 1.526
• Boiling Point: 351.8 °C at 760 mmHg
• PKA: 14.20±0.10(Predicted)
• Flash Point: 166.6 °C
• PSA: 57.61000
• Density: 1.327 g/cm³
• LogP: -0.93440
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Sparingly)

Purity/Quality:

99.9% ^*data from raw suppliers

N-(2-Hydroxyethyl)succinimide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-HYDROXYETHYL)SUCCINIMIDE

There total 10 articles about N-(2-HYDROXYETHYL)SUCCINIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(2,5-dioxopyrrolidin-1-yl)ethyl acetate (28833-81-0) → 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione (18190-44-8)

Guidance literature:

With acetyl chloride; In methanol; at 0 ℃; for 6h;

DOI:10.1039/d1ob00754h

Reference yield: 90.0%

Succinimide (123-56-8,89963-74-6) + ethanolamine (141-43-5) → 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione (18190-44-8)

Guidance literature:

at 200 ℃; for 2h;

DOI:10.1016/S0040-4039(00)82286-8

Reference yield: 90.0%

succinic acid anhydride (108-30-5) + ethanolamine (141-43-5) → 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione (18190-44-8)

Guidance literature:

at 200 ℃; for 2h;

DOI:10.1016/S0040-4020(01)96008-9

upstream raw materials:

[1,3]-dioxolan-2-one

Succinimide

succinic acid

ethanolamine

Downstream raw materials:

2-(2,5-dioxopyrrolidin-1-yl)ethyl acetate

1-(2-acetoxyethyl)-5-ethoxy-2-pyrrolidinone

(4R,5S)-1-aza-4-phenylthio-4-(hydroxymethyl)bicyclo<3.3.0>octan-8-one

(7R,7aS)-7-Benzenesulfinyl-7-hydroxymethyl-hexahydro-pyrrolizin-3-one

Refernces

• 1、 Pitkanen, Maija,Pitkanen, Ilkka,Eriksson, Hans-Erik,Autio, Pekka. "A NEW SYTHESIS AND CRYSTAL STRUCTURE OF N-(2-HYDROXYETHYL)SUCCINIMIDE". . p. 261 - 266. Retrieved 1988.
• 2、 -. "PROCESS FOR PREPARATION OF DIROXIMEL FUMARATE". Paragraph 0144. . Retrieved 2021/04/01.
• 3、 Argade, Narshinha P.,Shelar, Santosh V.. "Facile synthesis of indolizinoindolone, indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and isoindolopyrazinoindolone heterocycles from indole and imide derivatives". . p. 6160 - 6169. Retrieved 2021/07/21.