(2S,3S)-2-Amino-3-methoxybutanoic acid

Base Information

• Chemical Name: (2S,3S)-2-Amino-3-methoxybutanoic acid
• CAS No.: 104195-80-4
• Molecular Formula: C5H11 N O3
• Molecular Weight: 133.147
• Hs Code.: 2922509090
• Mol file: 104195-80-4.mol

Synonyms:2S,3S-2-Amino-3-methoxybutanoic acid;

Chemical Property of (2S,3S)-2-Amino-3-methoxybutanoic acid

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 220-224 ºC
• Refractive Index: 1.4206 (estimate)
• Boiling Point: 248 °C at 760 mmHg
• PKA: 2.12±0.10(Predicted)
• Flash Point: 103.8 °C
• PSA: 72.55000
• Density: 1.143 g/cm³
• LogP: -0.43220
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2S,3S)-2-Amino-3-methoxybutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,3S)-2-Amino-3-methoxybutanoic acid

There total 15 articles about (2S,3S)-2-Amino-3-methoxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-Trt-Thr (85918-01-0,115201-03-1) → O-methyl-L-threonine (2076-53-1,2076-57-5,4144-02-9,4385-90-4,34223-42-2,88642-93-7,104195-79-1,104195-80-4)

Guidance literature:

With acetic acid; In ethanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88549-5

Reference yield: 73.0%

Methyl (S)-3-methoxy-2-oxobutanoate (188906-12-9) → (2S,3S)-2-Amino-3-methoxybutanoic acid (104195-80-4)

Guidance literature:

With formate dehydrogenase; 1,4-dihydronicotinamide adenine dinucleotide; leucine dehydrogenase; ammonium formate; lipase;

DOI:10.1016/S0040-4039(97)00164-0

Reference yield:

→ 2-Amino-3-methoxybutanoic acid (2076-53-1,2076-57-5,4144-02-9,4385-90-4,34223-42-2,88642-93-7,104195-79-1,104195-80-4)

Guidance literature:

3-Methoxy-2-nitro-buttersaeure, MeOH, H2, Pt;

upstream raw materials:

methanol

Methyl (S)-3-methoxy-2-oxobutanoate

N-formyl-O-methyl-DL-allothreonine

O-methyl-N-benzoyl-DL-allothreonine

Downstream raw materials:

N-formyl-O-methyl-DL-allothreonine

N-formyl-O-methyl-DL-threonine

DL-threonine

O-methyl-N-benzoyl-DL-allothreonine

Refernces

• 1、 Zampella, Angela,Sepe, Valentina,Luciano, Paolo,Bellotta, Filomena,Monti, Maria Chiara,D'Auria, Maria Valeria,Jepsen, Trine,Petek, Sylvain,Adeline, Marie-Therese,Laprevote, Olivier,Aubertin, Anne-Marie,Debitus, Cecile,Poupat, Christiane,Ahond, Alain. "Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.". . p. 5319 - 5327. Retrieved 2008.
• 2、 Sutherland, Andrew,Willis, Christine L.. "Enantioselective syntheses of α-amino-β-hydroxy acids, [15N]-L-allothreonine and [15N]-L-threonine". . p. 1837 - 1840. Retrieved 2007/10/03.