3,4-dimethylbenzenesulfonyl fluoride

Base Information

• Chemical Name: 3,4-dimethylbenzenesulfonyl fluoride
• CAS No.: 57532-84-0
• Molecular Formula: C8H9FO2S
• Molecular Weight: 188.223
• Mol file: 57532-84-0.mol

Synonyms:

Chemical Property of 3,4-dimethylbenzenesulfonyl fluoride

Chemical Property:

• Vapor Pressure: 0.0295mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dimethylbenzenesulfonyl fluoride

There total 4 articles about 3,4-dimethylbenzenesulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Potassium; 3,4-dimethyl-benzenesulfonate (143018-82-0) → 3,4-dimethylbenzene-1-sulfonyl fluoride (57532-84-0)

Guidance literature:

With fluorosulphonic acid; for 1h; Ambient temperature;

Reference yield:

o-xylene (95-47-6) → bis(3,4-dimethylphenyl) sulfone (28361-43-5) + bis(2,3-dimethylphenyl) sulfone (49853-93-2) + 3,4-dimethylbenzene-1-sulfonyl fluoride (57532-84-0) + 1-((3,4-dimethylphenyl)sulfonyl)-2,3-dimethylbenzene (35907-73-4)

Guidance literature:

With antimony pentafluoride; fluorosulphonic acid; at 0 ℃; for 1h; Yield given. Further byproducts given. Yields of byproduct given;

DOI:10.1021/jo00039a046

Reference yield:

4-amino-o-xylene (95-64-7) → 3,4-dimethylbenzene-1-sulfonyl fluoride (57532-84-0)

Guidance literature:

4-amino-o-xylene; With tetrafluoroboric acid; tert.-butylnitrite; In ethanol; water; at 0 - 20 ℃;

With sodium metabisulfite; Selectfluor; In methanol; at 70 ℃; for 9h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00823

upstream raw materials:

o-xylene

Potassium; 3,4-dimethyl-benzenesulfonate

4-amino-o-xylene

Downstream raw materials:

3-(5-Fluorosulfonyl-2-methyl-benzyl)-4,5-dimethyl-benzenesulfonyl fluoride

Refernces

• 1、 Tanaka, Mutsuo,Souma, Yoshie. "Sulfonation of Aromatic Compounds in HSO3F-SbF5". . p. 3738 - 3740. Retrieved 2007/10/02.
• 2、 Arapov, O. V.,Rudenko, A. P.,Zarubin, M. Ya.. "OXIDATION OF METHYL-SUBSTITUTED BENZENESULFONYL FLUORIDES IN THE PbO2-HSO3F SYSTEM". . p. 152 - 163. Retrieved 2007/10/02.