1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL

Base Information

• Chemical Name: 1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL
• CAS No.: 5419-02-3
• Molecular Formula: C13H15 N O
• Molecular Weight: 201.268
• Hs Code.: 2922299090
• Mol file: 5419-02-3.mol

Synonyms:2-Naphthol,1-[(dimethylamino)methyl]- (6CI,8CI); 1-(Dimethylaminomethyl)-2-naphthol;2-Hydroxy-1-(dimethylaminomethyl)naphthalene; NSC 10556; NSC 651416

Chemical Property of 1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL

Chemical Property:

• Vapor Pressure: 0.000119mmHg at 25°C
• Melting Point: 76.5 °C
• Boiling Point: 325.8°Cat760mmHg
• PKA: 8.02±0.50(Predicted)
• Flash Point: 157.9°C
• PSA: 23.47000
• Density: 1.127g/cm³
• LogP: 2.60700

Purity/Quality:

99% ^*data from raw suppliers

1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL

There total 11 articles about 1-[(DIMETHYLAMINO)METHYL]-2-NAPHTHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

eschenmoser's salt (33797-51-2) + β-naphthol (135-19-3) → 1-dimethylaminomethyl-naphthalen-2-ol (5419-02-3)

Guidance literature:

With potassium carbonate; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1055/s-1983-30560

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) + β-naphthol (135-19-3) → 1-dimethylaminomethyl-naphthalen-2-ol (5419-02-3)

Guidance literature:

With magnesium sulfate; In neat (no solvent); at 20 ℃; for 3h;

DOI:10.14233/ajchem.2014.17618

Reference yield: 94.0%

bis-(dimethylamino)methane (51-80-9) + β-naphthol (135-19-3) → 1-dimethylaminomethyl-naphthalen-2-ol (5419-02-3)

Guidance literature:

With potassium carbonate; In chloroform; at 60 ℃; for 4h;

DOI:10.1016/j.poly.2020.114678

upstream raw materials:

formaldehyd

dimethyl amine

β-naphthol

bis-(dimethylamino)methane

Downstream raw materials:

1-<3-Oxo-2-phenyl-butyl>-naphthol-(2)

3-phenyl-1H-naphtho[1,2-e][1,3]oxazine

(1,2-dihydronaphtho[2,1-b]furan-2-yl)(4-hydroxyphenyl)methanone

(1H-benzo[f]chromen-2-yl)(4-chlorophenyl)methanone

Refernces

• 1、 Abdullin, Marat F.,Akhmadiev, Nail S.,Akhmetova, Vnira R.,Bikbulatova, El'mira M.,Ibragimov, Askhat G.,Mescheryakova, Ekaterina S.. "Synthesis of novel N- and S-derivatives of 2-naphthol – Promising ligands for the binuclear copper complexes". . . Retrieved 2020/07/06.
• 2、 Gonzalez, Paulina E.,Sharma, Hemant K.,Chakrabarty, Sanchita,Metta-Maga?a, Alejandro,Pannell, Keith H.. "Triethylsiloxymethyl-N,N-dimethylamine, Et3SiOCH2NMe2: A Dimethylaminomethylation (Mannich) Reagent for O–H, S–H, P–H and Aromatic C–H Systems". . p. 5610 - 5616. Retrieved 2017/10/13.