5-(5-ForMylfuran-2-yl)nicotinonitrile

Base Information

• Chemical Name: 5-(5-ForMylfuran-2-yl)nicotinonitrile
• CAS No.: 577975-32-7
• Molecular Formula: C₁₁H₆N₂O₂
• Molecular Weight: 198.181
• Mol file: 577975-32-7.mol

Synonyms:

Chemical Property of 5-(5-ForMylfuran-2-yl)nicotinonitrile

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

95+% ^*data from raw suppliers

5-(5-Formylfuran-2-yl)nicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(5-ForMylfuran-2-yl)nicotinonitrile

There total 2 articles about 5-(5-ForMylfuran-2-yl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

5-bromopyridine-3-carbonitrile (35590-37-5) + 5-formylfurane-2-boronic acid (27329-70-0) → 5-(5-cyanopyridin-3-yl)-furan-2-carbaldehyde (577975-32-7)

Guidance literature:

With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 95 ℃; for 110h;

DOI:10.1039/b302767h

Reference yield:

2-(diethoxymethyl)furan (13529-27-6) → 5-(5-cyanopyridin-3-yl)-furan-2-carbaldehyde (577975-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 5 h / -78 °C

1.2: trimethylborate / tetrahydrofuran; hexane / -78 - 25 °C

1.3: 52 percent / aq. NaOH / pH 10

2.1: 15 percent / Cs₂CO₃ / Pd(PPh₃)2Cl₂ / dioxane / 110 h / 95 °C

With n-butyllithium; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; hexane; 2.1: Suzuki-Miyaura cross-coupling reaction;

DOI:10.1039/b302767h

upstream raw materials:

5-bromopyridine-3-carbonitrile

5-formylfurane-2-boronic acid

2-(diethoxymethyl)furan

Refernces