Technology Process of 7-(5-deoxy-3-O-methyl-beta-D-erythro-pent-4-enofuranosyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
There total 8 articles about 7-(5-deoxy-3-O-methyl-beta-D-erythro-pent-4-enofuranosyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; triethylamine;
at 50 ℃;
for 5h;
DOI:10.3390/md17040226
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere
1.2: 4.25 h / 0 - 80 °C / Inert atmosphere
2.1: ammonia / methanol / 12 h / 40 °C / Autoclave
3.1: acetic acid; sodium nitrite / water / 8 h / 60 °C
4.1: triethylamine; palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 20 °C
5.1: tributylphosphine; pyridine / 4 h / 20 °C / Inert atmosphere
6.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 20 °C
7.1: triethylamine; pyridine / 5 h / 50 °C
With
pyridine; N,O-bis-(trimethylsilyl)-acetamide; tributylphosphine; palladium on activated charcoal; ammonia; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; sodium nitrite;
In
tetrahydrofuran; methanol; water; acetonitrile;
1.1: |Vorbrueggen Nucleoside Synthesis;
DOI:10.3390/md17040226
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.33 h / 50 °C / Inert atmosphere
1.2: 4.25 h / 0 - 80 °C / Inert atmosphere
2.1: ammonia / methanol / 12 h / 40 °C / Autoclave
3.1: acetic acid; sodium nitrite / water / 8 h / 60 °C
4.1: triethylamine; palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 20 °C
5.1: tributylphosphine; pyridine / 4 h / 20 °C / Inert atmosphere
6.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 20 °C
7.1: triethylamine; pyridine / 5 h / 50 °C
With
pyridine; N,O-bis-(trimethylsilyl)-acetamide; tributylphosphine; palladium on activated charcoal; ammonia; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; sodium nitrite;
In
tetrahydrofuran; methanol; water; acetonitrile;
1.1: |Vorbrueggen Nucleoside Synthesis;
DOI:10.3390/md17040226