Imidazo[1,2-a]pyridine-2-carboxylate

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-2-carboxylate
• CAS No.: 64951-08-2
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 29332900
• DSSTox Substance ID: DTXSID90983510
• Wikidata: Q72482560
• Mol file: 64951-08-2.mol

Synonyms:imidazo[1,2-a]pyridine-2-carboxylate;DTXSID90983510;WQLJLPDGSLZYEP-UHFFFAOYSA-M

Chemical Property of Imidazo[1,2-a]pyridine-2-carboxylate

Chemical Property:

• Melting Point: 232-234℃
• PKA: -4.33±0.41(Predicted)
• PSA: 54.60000
• Density: 1.41 g/cm³
• LogP: 1.03250
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 161.035102407
• Heavy Atom Count: 12
• Complexity: 190

Purity/Quality:

98% ^*data from raw suppliers

Imidazo[1,2-a]pyridine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)C(=O)[O-]

Technology Process of Imidazo[1,2-a]pyridine-2-carboxylate

There total 5 articles about Imidazo[1,2-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ imidazo[1,2-a]pyridine-2-carboxylic acid (64951-08-2)

Guidance literature:

Reference yield: 75.3%

2-aminopyridine (504-29-0) + bromopyruvic acid (1113-59-3) → imidazo[1,2-a]pyridine-2-carboxylic acid (64951-08-2)

Guidance literature:

In ethanol; at 80 ℃; for 8h;

DOI:10.1039/c9nj03462e

Reference yield: 73.0%

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate (38922-77-9) → imidazo[1,2-a]pyridine-2-carboxylic acid (64951-08-2)

Guidance literature:

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate; With ethanol; water; sodium hydroxide; at 60 ℃; for 3h;

With hydrogenchloride; In water;

upstream raw materials:

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate

2-aminopyridine

bromopyruvic acid

Downstream raw materials:

C₂₀H₂₀F₂N₄O

3-({[(1R)-1-(4-fluorophenyl)ethyl](imidazo[1,2-a]pyridin-2-ylcarbonyl)amino}methyl)benzoic acid

C₂₅H₂₂FN₃O₃

N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide

Refernces

• 1、 Lahm, George P.,Desaeger, Johan,Smith, Ben K.,Pahutski, Thomas F.,Rivera, Michel A.,Meloro, Tony,Kucharczyk, Roman,Lett, Renee M.,Daly, Anne,Smith, Brenton T.,Cordova, Daniel,Thoden, Tim,Wiles, John A.. "The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes". . p. 1572 - 1575. Retrieved 2017/03/17.
• 2、 -. "NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE". Page/Page column 31. . Retrieved 2010/07/04.