2'-Deoxyinosine

Base Information

• Chemical Name: 2'-Deoxyinosine
• CAS No.: 890-38-0
• Molecular Formula: C10H12N4O4
• Molecular Weight: 252.23
• Hs Code.: 29349990
• Mol file: 890-38-0.mol

Synonyms:6H-Purin-6-one, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-;9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one;Deoxyinosine;Hypoxanthine deoxyriboside;Hypoxanthine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-;

Chemical Property of 2'-Deoxyinosine

Chemical Property:

• Appearance/Colour: Crystalline
• Melting Point: 250 °C
• Refractive Index: -16 ° (C=1, H2O)
• Boiling Point: 681.2 °C at 760 mmHg
• PKA: 8.92±0.70(Predicted)
• Flash Point: 365.8 °C
• PSA: 113.26000
• Density: 1.91 g/cm³
• LogP: -1.23970
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Water (Slightly)
• Water Solubility.: 8.33g/L(25.02 oC)

Purity/Quality:

99% ^*data from raw suppliers

Di ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-37/39-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: An Inosine (I661000) analog with hypotensive activity. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950). 2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a standard for high performance liquid chromatography analysis.

Technology Process of 2'-Deoxyinosine

There total 33 articles about 2'-Deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

hypoxanthine (68-94-0) + 7-methyl-2′-deoxyguanosine hydroiodide → 2-deoxyinosine (890-38-0)

Guidance literature:

With potassium dihydrogenphosphate; Escherichia coli purine nucleoside phosphorylase; In aq. buffer; at 20 ℃; for 20h; pH=7.5; Enzymatic reaction;

DOI:10.1002/adsc.201701005

Reference yield: 91.0%

2'-deoxy-D-adenosine (958-09-8,7005-15-4) → 2-deoxyinosine (890-38-0)

Guidance literature:

With potassium dihydrogenphosphate; for 24h; adenosine deaminase type II;

DOI:10.1021/jo00124a027

Reference yield: 40.0%

N1-hydroxy-2'-deoxyinosine (194287-64-4) → 2-deoxyinosine (890-38-0) + 2'-deoxyxanthosine (29049-22-7,25843-96-3) + 2'-deoxyoxanosine (88899-00-7)

Guidance literature:

In water; for 2h; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(98)01605-0

upstream raw materials:

triethylamine carbonate

2'-deoxy-D-adenosine

N₁-hydroxy-2'-deoxyinosine

9-(3',5'-di-O-acetyl-2'-deoxy-β-D-erythro-pentofuranosyl)-1H-purine-6(9H)-one

Downstream raw materials:

5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine

7-benzylhypoxanthine

1,7-dibenzylhypoxanthine

3,7-dibenzylhypoxanthine

Refernces

• 1、 Kaspar, Felix,Giessmann, Robert T.,Neubauer, Peter,Wagner, Anke,Gimpel, Matthias. "Thermodynamic Reaction Control of Nucleoside Phosphorolysis". supporting information. p. 867 - 876. Retrieved 2020/01/24.
• 2、 Annunziata, Francesca,Bavaro, Teodora,Calleri, Enrica,Conti, Paola,Pinto, Andrea,Previtali, Clelia,Rinaldi, Francesca,Speranza, Giovanna,Tamborini, Lucia,Terreni, Marco,Ubiali, Daniela. "An enzymatic flow-based preparative route to vidarabine". . . Retrieved 2020/03/23.