2-(2,4-Difluorophenyl)-5-methylpyridine, 95%

Base Information

• Chemical Name: 2-(2,4-Difluorophenyl)-5-methylpyridine, 95%
• CAS No.: 583052-21-5
• Molecular Formula: C12H9F2N
• Molecular Weight: 205.20300
• Mol file: 583052-21-5.mol

Synonyms:2-(2,4-Difluoro-phenyl)-5-methyl-pyridine;2-(2',4'-difluorophenyl)-5-methylpyridine;2-(2,4-difluoro-phenyl)-5-methylpyridine;dFmppy;2-(2,4-difluorophenyl)-5-methylpyridine;

Chemical Property of 2-(2,4-Difluorophenyl)-5-methylpyridine, 95%

Chemical Property:

• Melting Point: 55 °C
• Boiling Point: 272.7±35.0 °C(Predicted)
• PKA: 4.20±0.27(Predicted)
• PSA: 12.89000
• Density: 1.188±0.06 g/cm3(Predicted)
• LogP: 3.33520
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: air sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2,4-Difluorophenyl)-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: This ligand is used in Ir(III) complexes suitable for use in photocatalysis and phosphorescent OLEDs.

Technology Process of 2-(2,4-Difluorophenyl)-5-methylpyridine, 95%

There total 4 articles about 2-(2,4-Difluorophenyl)-5-methylpyridine, 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-(2-(2,4-difluorophenyl)-2-oxoethyl)pyridin-1-ium bromide + 2-methylpropenal (78-85-3,25120-30-3) → 5-methyl-2-[(2,4-difluorophenyl)-2-oxoethyl]pyridine (583052-21-5)

Guidance literature:

With ammonium acetate; In methanol; at 65 ℃;

DOI:10.1021/jacs.6b03246

Reference yield: 43.0%

2-Bromo-5-methylpyridine (3510-66-5) + 2,4-difluorophenylboronic acid (144025-03-6) → 5-methyl-2-[(2,4-difluorophenyl)-2-oxoethyl]pyridine (583052-21-5)

Guidance literature:

With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); In tetrahydrofuran; water; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.9b08746

Reference yield:

2-bromo-2',4'-difluoroacetophenone (102429-07-2) → 5-methyl-2-[(2,4-difluorophenyl)-2-oxoethyl]pyridine (583052-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 °C

2: ammonium acetate / methanol / 15 h / Heating

With ammonium acetate; In methanol;

DOI:10.1021/ja0427101

upstream raw materials:

2-methylpropenal

2-bromo-2',4'-difluoroacetophenone

2-Bromo-5-methylpyridine

2,4-difluorophenylboronic acid

Refernces

• 1、 Miller, David C.,Ganley, Jacob M.,Musacchio, Andrew J.,Sherwood, Trevor C.,Ewing, William R.,Knowles, Robert R.. "Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines". supporting information. p. 16590 - 16594. Retrieved 2019/11/03.
• 2、 Goldsmith, Jonas I.,Hudson, William R.,Lowry, Michael S.,Anderson, Timothy H.,Bernhard, Stefan. "Discovery and high-throughput screening of heteroleptic iridium complexes for photoinduced hydrogen production". . p. 7502 - 7510. Retrieved 2007/10/03.