N-(P-TOLYL)-2-NAPHTHYLAMINE

Base Information

• Chemical Name: N-(P-TOLYL)-2-NAPHTHYLAMINE
• CAS No.: 644-16-6
• Molecular Formula: C17H15N
• Molecular Weight: 233.313
• Hs Code.: 2921499090
• Mol file: 644-16-6.mol

Synonyms:(4-Methylphenyl)-2-naphthylamine;

Chemical Property of N-(P-TOLYL)-2-NAPHTHYLAMINE

Chemical Property:

• Vapor Pressure: 5.47E-07mmHg at 25°C
• Melting Point: 102-103℃
• Refractive Index: 1.685
• Boiling Point: 411.7 °C at 760 mmHg
• PKA: 1.33±0.30(Predicted)
• Flash Point: 219.6 °C
• PSA: 12.03000
• Density: 1.133 g/cm³
• LogP: 4.96480
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

N-(4-Methylphenyl)naphthalen-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(P-TOLYL)-2-NAPHTHYLAMINE

There total 19 articles about N-(P-TOLYL)-2-NAPHTHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromonaphthalene (580-13-2) + p-toluidine (106-49-0,12221-03-3) → N-(p-tolyl)naphthalen-2-amine (644-16-6)

Guidance literature:

With ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; In water; at 20 ℃; for 3h; Inert atmosphere; Micellar solution;

DOI:10.1002/adsc.200900323

Reference yield: 96.0%

2,2'-sulfinyldinaphthalene (647829-48-9) + p-toluidine (106-49-0,12221-03-3) → N-(p-tolyl)naphthalen-2-amine (644-16-6)

Guidance literature:

With SingaCycle-A₁; sodium t-butanolate; In tetrahydrofuran; at 60 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00060

Reference yield: 95.0%

naphthalene-2-boronic acid (32316-92-0) + p-toluidine (106-49-0,12221-03-3) → N-(p-tolyl)naphthalen-2-amine (644-16-6)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; at 0 - 5 ℃; for 4h; Sonication; Green chemistry;

DOI:10.3987/COM-14-S(K)18

upstream raw materials:

1-Bromonaphthalene

p-toluidine

sodium 2-naphthol-6-sulfonate

β-naphthol

Downstream raw materials:

14-(3-methoxy-phenyl)-7-p-tolyl-7,14-dihydro-dibenz[a,j]acridine

11-oxo-9,9-dimethyl-7-(p-tolyl)-8,9,10,11-tetrahydrobenzoacridinium bromide

9,9-Dimethyl-11-oxo-7-(p-tolyl)-7,7a,8,9,10,11-hexahydrobenzo(7,7-dimethyl-5-oxo-5,6,7,8(2H)-tetrahydrochromeno)<2,3-q>acridine

N,N'-di-p-tolyl-[1,1']binaphthyl-2,2'-diyldiamine

Refernces

• 1、 Borlinghaus, Niginia,Kaschel, Johannes,Klee, Johanna,Haller, Vanessa,Schetterl, Jasmin,Heitz, Stephanie,Lindner, Tanja,Dietrich, Justin D.,Braje, Wilfried M.,Jolit, Anais. "Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis". supporting information. p. 1357 - 1370. Retrieved 2020/12/21.
• 2、 Wang, Dan,Wan, Zhaohua,Zhang, Heng,Alhumade, Hesham,Yi, Hong,Lei, Aiwen. "Electrochemical Reductive Arylation of Nitroarenes with Arylboronic Acids". . p. 5399 - 5404. Retrieved 2021/10/20.