3(5)-BroMo-4-Methylpyrazole

Base Information

• Chemical Name: 3(5)-BroMo-4-Methylpyrazole
• CAS No.: 5932-20-7
• Molecular Formula: C4H5BrN2
• Molecular Weight: 161.00000
• Hs Code.: 2933199090
• Mol file: 5932-20-7.mol

Synonyms:3-Brom-4-methyl-pyrazol;3-Brom-4-methyl-pyrazol bzw. 5-Brom-4-methyl-pyrazol;3-Bromo-4-methyl-1H-pyrazole;3-bromo-4-methyl-1(2)H-pyrazole;3(5)-BROMO-4-METHYLPYRAZOLE;3-Brom-4-methyl-1(2)H-pyrazol;3-bromo-4-methyl-pyrazole;

Chemical Property of 3(5)-BroMo-4-Methylpyrazole

Chemical Property:

• Melting Point: 127-128 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 271.6±20.0 °C(Predicted)
• PKA: 11.83±0.50(Predicted)
• PSA: 28.68000
• Density: 1.723±0.06 g/cm3(Predicted)
• LogP: 1.48060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%HPLC ^*data from raw suppliers

3-Bromo-4-methyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3(5)-BroMo-4-Methylpyrazole

There total 4 articles about 3(5)-BroMo-4-Methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-bromo-1,4-dimethyl-4,5-dihydro-1H-pyrazole → 3-bromo-4-methyl-1H-pyrazole (5932-20-7) + 3-bromo-1,4-dimethyl-1H-pyrazole (13745-59-0)

Guidance literature:

With sodium hypochlorite; potassium phosphate; potassium bromide; In dichloromethane; water; at 0 - 5 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.7b03282

Reference yield:

3-bromo-4-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole → 3-bromo-4-methyl-1H-pyrazole (5932-20-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3h;

Reference yield:

5-bromo-4-methyl-1H-pyrazole-3-carboxylic acid (929554-40-5) → 3-bromo-4-methyl-1H-pyrazole (5932-20-7)

Guidance literature:

at 340 ℃;

upstream raw materials:

5-bromo-4-methyl-1H-pyrazole-3-carboxylic acid

Refernces

• 1、 -. "COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM". Paragraph 00542. . Retrieved 2015/04/28.