Technology Process of Benzenemethanamine, 4-(1-methylethyl)-, hydrochloride
There total 2 articles about Benzenemethanamine, 4-(1-methylethyl)-, hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(azidomethyl)-4-isopropylbenzene;
With
1,3-diphenyl-disiloxane; triphenylphosphine;
at 20 ℃;
for 24h;
With
water;
With
hydrogenchloride;
In
1,4-dioxane;
chemoselective reaction;
DOI:10.1021/acs.joc.9b00831
- Guidance literature:
-
4-methylisopropylbenzene;
With
Benzophenone imine; 1-methoxy-3,3-dimethyl-1,2-benziodoxole;
In
1,2-dichloro-ethane;
at 75 ℃;
for 24h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water;
at 45 ℃;
for 24h;
Overall yield = 81percent; Overall yield = 0.03 g;
Inert atmosphere;
DOI:10.1002/chem.202102627
- Guidance literature:
-
N-(benzyloxycarbonyl)-D-serine;
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
4-isopropylbenzylamine hydrochloride;
With
4-methyl-morpholine;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jm901563p
