4-chlorophenylhydroxylamine

Base Information

• Chemical Name: 4-chlorophenylhydroxylamine
• CAS No.: 823-86-9
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Mol file: 823-86-9.mol

Synonyms:Hydroxylamine,N-(p-chlorophenyl)- (6CI,7CI,8CI);4-Chloro-N-hydroxybenzenamine;4-Chlorophenylhydroxamic acid;4-Chlorophenylhydroxylamine;N-(4-Chlorophenyl)hydroxylamine;N-(p-Chlorophenyl)hydroxylamine;N-Hydroxy-4-chloroaniline;N-Hydroxy-4-chlorobenzenamine;NSC 166794;NSC528511;p-Chlorophenylhydroxylamine;

Chemical Property of 4-chlorophenylhydroxylamine

Chemical Property:

• Vapor Pressure: 0.0106mmHg at 25°C
• Melting Point: 86 °C
• Refractive Index: 1.661
• Boiling Point: 251.7 °C at 760 mmHg
• PKA: 8.30±0.70(Predicted)
• Flash Point: 106 °C
• PSA: 32.26000
• Density: 1.409g/cm³
• LogP: 2.21410

Purity/Quality:

99% ^*data from raw suppliers

4-Chlorophenylhydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chlorophenylhydroxylamine

There total 23 articles about 4-chlorophenylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorobenzonitrile (100-00-5) → N-(4-chlorophenyl)hydroxylamine (823-86-9)

Guidance literature:

With Ru-Starbon; hydrazine hydrate; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere; Green chemistry;

DOI:10.1039/c4cc09192b

Reference yield: 88.0%

4-ClC6H4-N(Teoc)OTBS (1303610-38-9) → N-(4-chlorophenyl)hydroxylamine (823-86-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 40 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.034

Reference yield: 53.0%

4-chlorobenzonitrile (100-00-5) → 4-chloro-aniline (106-47-8) + aniline (62-53-3) + N-(4-chlorophenyl)hydroxylamine (823-86-9)

Guidance literature:

With hydrogen; In tetrahydrofuran; N,N-dimethyl-formamide; at 30 ℃; for 5h; under 6080.41 Torr; chemoselective reaction; Inert atmosphere; Autoclave;

DOI:10.1016/j.tetlet.2015.04.116

upstream raw materials:

4-chlorobenzonitrile

N-(p-chlorophenyl)-2-furohydroxamic acid

GLUTATHIONE

1-chloro-4-nitroso-benzene

Downstream raw materials:

N-(4-chlorophenyl)-α-phenylnitrone

N-(salicylidene)-4-chlorophenylamine-N-oxide

N,O-dibenzoyl-N-(4-chloro-phenyl)-hydroxylamine

4,4'-bis(chloro)azoxybenzene

Refernces

• 1、 Du, Yuanbo,Feng, Lei,Gao, Hongyin,Guo, Lirong,Lu, Haifeng,Xi, Zhenguo. "Practical bromination of arylhydroxylamines with SOBr2 towards ortho-bromo-anilides". supporting information. . Retrieved 2021/05/19.
• 2、 Ioannou, Dimitris I.,Gioftsidou, Dimitra K.,Tsina, Vasiliki E.,Kallitsakis, Michael G.,Hatzidimitriou, Antonios G.,Terzidis, Michael A.,Angaridis, Panagiotis A.,Lykakis, Ioannis N.. "Selective Reduction of Nitroarenes to Arylamines by the Cooperative Action of Methylhydrazine and a Tris(N-heterocyclic thioamidate) Cobalt(III) Complex". supporting information. p. 2895 - 2906. Retrieved 2021/02/27.