4-(chloromethyl)-2-thiazolamine

Base Information

• Chemical Name: 4-(chloromethyl)-2-thiazolamine
• CAS No.: 7250-84-2
• Molecular Formula: C4H5 Cl N2 S
• Molecular Weight: 148.616
• Hs Code.: 2934100090
• Mol file: 7250-84-2.mol

Synonyms:Thiazole,2-amino-4-(chloromethyl)- (6CI,8CI); 2-Amino-4-(chloromethyl)thiazole;4-(Chloromethyl)-1,3-thiazol-2-amine; 4-(Chloromethyl)-2-thiazolamine; NSC30215

Chemical Property of 4-(chloromethyl)-2-thiazolamine

Chemical Property:

• Boiling Point: 299.7°Cat760mmHg
• Flash Point: 135°C
• PSA: 67.15000
• Density: 1.455g/cm³
• LogP: 2.04530
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloromethyl-thiazol-2-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(chloromethyl)-2-thiazolamine

There total 4 articles about 4-(chloromethyl)-2-thiazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

thiourea (17356-08-0) + chloroacetone (78-95-5) → 2-Amino-4-chloromethyl-1,3-thiazole (7250-84-2)

Guidance literature:

With carbon tetrabromide; triethylamine; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2015.08.064

Reference yield:

thiourea (17356-08-0) + 1,3-Dichloroacetone (534-07-6) → 2-Amino-4-chloromethyl-1,3-thiazole (7250-84-2) + S-<(2-amino-4-thiazolyl)methyl>isothiourea dihydrochloride (20167-22-0)

Guidance literature:

With acetone;

DOI:10.1021/ja01215a010

Reference yield:

1,3-Dichloroacetone (534-07-6) → 2-Amino-4-chloromethyl-1,3-thiazole (7250-84-2)

Guidance literature:

With thiourea; In methanol;

upstream raw materials:

thiourea

1,3-Dichloroacetone

chloroacetone

Downstream raw materials:

N-(4-chloromethylthiazol-2-yl)-3-(4-methanesulfonylphenoxy)-5-(3-methylpyridine-2-yl)benzamide

N-{4-chloromethyl-1,3-thiazol-2-yl}-3-(1-methylethyl)oxy-5-[4-(methylsulfonyl)phenoxy]benzamide

N-(4-(chloromethyl)thiazol-2-yl)acetamide

4-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}-1,3-thiazol-2-amine

Refernces

• 1、 Ghodse, Shrikant M.,Telvekar, Vikas N.. "Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl/aryl ketones using aqueous NaICl2". . p. 472 - 474. Retrieved 2015/03/05.
• 2、 -. "7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof". . . Retrieved 2008/06/13.