Pyridoxamine phosphate

Base Information

• Chemical Name: Pyridoxamine phosphate
• CAS No.: 529-96-4
• Molecular Formula: C8H13N2O5P
• Molecular Weight: 248.175
• Hs Code.: 2933399090
• European Community (EC) Number: 208-471-6
• UNII: Q05R77UO7P
• DSSTox Substance ID: DTXSID3046825
• Nikkaji Number: J11.364F
• Wikidata: Q27093205
• NCI Thesaurus Code: C81631
• Metabolomics Workbench ID: 37868
• ChEMBL ID: CHEMBL1235353
• Mol file: 529-96-4.mol

Synonyms:pyridoxamine phosphate;pyridoxamine phosphate hydrochloride;pyridoxamine-P

Chemical Property of Pyridoxamine phosphate

Chemical Property:

• Boiling Point: 607.3°Cat760mmHg
• PKA: pKa 8.61(H2O t = 25 I = 0.15)(Approximate)
• Flash Point: 321.1°C
• PSA: 135.71000
• Density: 1.559g/cm³
• LogP: 0.86390
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 248.05620852
• Heavy Atom Count: 16
• Complexity: 271

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyridoxamine-5′-phosphate ≥98.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC=C(C(=C1O)CN)COP(=O)(O)O
• Uses: Pyridoxamine-5''-phosphate is a chromophore that plays a crucial role in the biosynthesis of deoxysugars (e.g. 2-Deoxy-2-chloro-D-glucose [D232570]). Pyridoxamine-5''-phosphate is naturally found in rat liver.

Technology Process of Pyridoxamine phosphate

There total 20 articles about Pyridoxamine phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

pyridoxamine (85-87-0) → pyridoxamine-5'-phosphate (529-96-4)

Guidance literature:

With phosphoric acid; at 100 ℃; for 8h;

DOI:10.1271/bbb.70090

Reference yield:

D-Fructose (57-48-7,18875-34-8) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → pyridoxamine-5'-phosphate (529-96-4) + pyridoxal 5'-phosphate (54-47-7) + pyridoxal (66-72-8) + pyridoxamine (85-87-0)

Guidance literature:

With air; ATCC 38399 h^- leu1-32; In various solvent(s); at 30 ℃; for 36h; pH=4.5; Further Variations:; Reagents; reaction times; Product distribution; Microbiological reaction;

DOI:10.1271/bbb.65.1789

Reference yield:

D-Glucose (2280-44-6) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → pyridoxamine-5'-phosphate (529-96-4) + pyridoxal 5'-phosphate (54-47-7) + pyridoxal (66-72-8) + pyridoxamine (85-87-0)

Guidance literature:

With air; ATCC 38399 h^- leu1-32; In various solvent(s); at 30 ℃; for 36h; pH=4.5; Further Variations:; Reagents; reaction times; Product distribution; Microbiological reaction;

DOI:10.1271/bbb.65.1789

upstream raw materials:

L-glutamic acid

pyridoxal 5'-phosphate

pyridoxamine dihydrochloride

pyridoxamine

Downstream raw materials:

pyridoxamine

4-pyridoxic acid 5'-phosphate

pyridoxal 5'-phosphate

Refernces

• 1、 Heyl et al.. "-". . p. 3437. Retrieved 1951.
• 2、 Sakai, Miwa,Hirata, Hiroshi,Sayama, Hironori,Sekiguchi, Kazuya,Itano, Hiroaki,Asai, Tatsuo,Dohra, Hideo,Hara, Masakazu,Watanabe, Naoharu. "Production of 2-phenylethanol in roses as the dominant floral scent compound from L-phenylalanine by two key enzymes, a PLP-dependent decarboxylase and a phenylacetaldehyde reductase". . p. 2408 - 2419. Retrieved 2007.
• 3、 Hill, Melissa P.,Carroll, Elizabeth C.,Vang, Mai C.,Addington, Trevor A.,Toney, Michael D.,Larsen, Delmar S.. "Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase". supporting information; experimental part. p. 16953 - 16961. Retrieved 2011/02/16.