Technology Process of 3-Pyridineacetic acid, 5-phenyl-, methyl ester
There total 1 articles about 3-Pyridineacetic acid, 5-phenyl-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bromobenzene;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2h;
(5-bromo-pyridin-3-yl)-acetic acid methyl ester;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate;
In
N,N-dimethyl-formamide;
at 85 ℃;
DOI:10.1021/jm0301078
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: LDA / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / -78 - 20 °C
2.1: H2 / Pd/C / ethanol / 8 h / 2068.59 Torr
With
hydrogen; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
DOI:10.1021/jm0301078
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / -78 - 20 °C
2.1: H2 / Pd/C / ethanol / 8 h / 2068.59 Torr
3.1: aq. LiOH / methanol / 20 °C
With
lithium hydroxide; hydrogen; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm0301078
