4-Acetoxyisophthalic Acid

Base Information

• Chemical Name: 4-Acetoxyisophthalic Acid
• CAS No.: 5985-26-2
• Molecular Formula: C10H8O6
• Molecular Weight: 224.16700
• Hs Code.: 2918990090
• Mol file: 5985-26-2.mol

Synonyms:4-acetoxy-1H-indole-6-carboxylic acid methyl ester;acetic acid 1H-indol-4-yl ester;4-ACETOXYINDOL;ACETOXYINDOLE;4-Acetoxy-6-methoxycarbonyl-indole;4-acetylindole;acetic acid indol-4-yl ester;4-Acetoxy indole;Methyl-4-acetoxy-indol-6-carboxylat;4-Acetoxy-isophthalsaeure;4-indolyl acetate;Essigsaeure-indol-4-ylester;4-Indoxyl acetate;4-acetoxy-isophthalic acid;4-acetoxy-indole-6-carboxylic acid methyl ester;

Chemical Property of 4-Acetoxyisophthalic Acid

Chemical Property:

• Melting Point: >170°C (dec.)
• PSA: 100.90000
• LogP: 1.00830
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Methanol (Slightly))

Purity/Quality:

95% ^*data from raw suppliers

4-AcetoxyisophthalicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Acetoxyisophthalic Acid is a derivative of Isophthalic Acid and also an synthetic intermediate in various preparations.

Technology Process of 4-Acetoxyisophthalic Acid

There total 3 articles about 4-Acetoxyisophthalic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxyisophthalic acid (636-46-4) + acetic anhydride (108-24-7) → 4-(acetoxy)isophthalic acid (5985-26-2)

Guidance literature:

With diethyl ether; at 20 ℃;

Reference yield:

dimethyl 4-hydroxyisophthalate (5985-24-0) → 4-(acetoxy)isophthalic acid (5985-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; bromine; H₂O

2: aqueous KOH; copper-powder

3: diethyl ether / 20 °C

With methanol; potassium hydroxide; diethyl ether; water; bromine; copper;

Reference yield:

5-bromo-4-hydroxyisophthalic acid dimethyl ester (54176-51-1) → 4-(acetoxy)isophthalic acid (5985-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH; copper-powder

2: diethyl ether / 20 °C

With potassium hydroxide; diethyl ether; copper;

upstream raw materials:

4-hydroxyisophthalic acid

acetic anhydride

dimethyl 4-hydroxyisophthalate

5-bromo-4-hydroxyisophthalic acid dimethyl ester