3-methyl-1-benzofuran-2-carbaldehyde(SALTDATA: FREE)

Base Information

• Chemical Name: 3-methyl-1-benzofuran-2-carbaldehyde(SALTDATA: FREE)
• CAS No.: 1199-07-1
• Molecular Formula: C10H8 O2
• Molecular Weight: 160.1693
• Hs Code.: 2932990090
• Mol file: 1199-07-1.mol

Synonyms:2-Formyl-3-methylbenzofuran;3-Methyl-2-benzofurancarboxaldehyde; 3-Methylbenzofuran-2-aldehyde

Chemical Property of 3-methyl-1-benzofuran-2-carbaldehyde(SALTDATA: FREE)

Chemical Property:

• Vapor Pressure: 0.00453mmHg at 25°C
• Boiling Point: 277.4°Cat760mmHg
• Flash Point: 124.4°C
• PSA: 30.21000
• Density: 1.192g/cm³
• LogP: 2.55370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-1-benzofuran-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methyl-1-benzofuran-2-carbaldehyde(SALTDATA: FREE)

There total 13 articles about 3-methyl-1-benzofuran-2-carbaldehyde(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-methyl-2-vinylbenzofuran (53327-15-4) → 3-methylbenzofuran-2-carboxaldehyde (1199-07-1)

Guidance literature:

With 2,6-dimethylpyridine; potassium osmate(VI) dihydrate; sodium periodate; In 1,4-dioxane; water; at 20 ℃; for 1h;

DOI:10.1021/acs.orglett.7b00985

Reference yield: 65.0%

2-(hydroxymethyl)-3-methylbenzofuran (55581-62-9) → 3-methylbenzofuran-2-carboxaldehyde (1199-07-1)

Guidance literature:

With manganese(IV) oxide; In benzene; Ambient temperature;

DOI:10.1021/jm00099a007

Reference yield: 63.0%

ethyl 3-methyl-1-benzofuran-2-carboxylate (22367-82-4) → 3-methylbenzofuran-2-carboxaldehyde (1199-07-1)

Guidance literature:

ethyl 3-methyl-1-benzofuran-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

With Dess-Martin periodane; In dichloromethane;

DOI:10.1039/c6ob02569b

upstream raw materials:

2-(hydroxymethyl)-3-methylbenzofuran

3-methyl-1-benzofuran-2-carboxylic acid

methyl 3-methylbenzofuran-2-carboxylate

o-hydroxyacetophenone

Downstream raw materials:

4-(3-methyl-benzofuran-2-ylmethylene)-2-phenyl-4H-oxazol-5-one

(E)-4-(3-Methyl-benzofuran-2-yl)-3-phenyl-but-3-en-2-one

5-[(E)-2-(3-Methyl-benzofuran-2-yl)-vinyl]-1-phenyl-1H-pyrazole-3-carboxylic acid

5-[(E)-2-(3-Methyl-benzofuran-2-yl)-1-phenyl-vinyl]-1H-pyrazole-3-carboxylic acid

Refernces

• 1、 -. "COMPOUNS, COMPOSITIONS AND METHODS OF USE". . . Retrieved 2018/07/29.
• 2、 Ohno, Shohei,Takamoto, Kohei,Fujioka, Hiromichi,Arisawa, Mitsuhiro. "Cycloisomerization between Aryl Enol Ether and Silylalkynes under Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans". . p. 2422 - 2425. Retrieved 2017/05/12.