2-Chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide

Base Information

• Chemical Name: 2-Chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide
• CAS No.: 59908-77-9
• Molecular Formula: C12H14ClNO4
• Molecular Weight: 271.7
• European Community (EC) Number: 813-608-3
• UNII: X4Z8TB7GBA
• Mol file: 59908-77-9.mol

Synonyms:2-chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide;X4Z8TB7GBA;59908-77-9;SCHEMBL5844239;FGAJXUVYQBZJHH-UHFFFAOYSA-N;2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-oxoethyl]acetamide;Acetamide, 2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-oxoethyl]-

Chemical Property of 2-Chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 271.0611356
• Heavy Atom Count: 18
• Complexity: 298

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)C(=O)CNC(=O)CCl

Technology Process of 2-Chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide

There total 1 articles about 2-Chloro-n-(beta-oxo-2,5-dimethoxy phenethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride (671224-08-1) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(β-oxo-2',5'-dimethoxyphenethyl)acetamide (59908-77-9)

Guidance literature:

With sodium acetate; In water; acetone; at 0 ℃; for 0.5h; pH=5;

Reference yield: 91.0%

2-chloro-N-(β-oxo-2',5'-dimethoxyphenethyl)acetamide (59908-77-9) → 2-azido-N-(β-oxo-2',5'-dimethoxyphenethyl)acetamide (59939-34-3)

Guidance literature:

With sodium azide; potassium iodide; In acetone; at 60 ℃; for 5h;

upstream raw materials:

2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride

chloroacetyl chloride

Downstream raw materials:

2-azido-N-(β-oxo-2',5'-dimethoxyphenethyl)acetamide

Refernces

• 1、 -. "Process for the synthesis of (+) 2-amino-n-{2, (2,5-dimethoxy phenyl)-2-hydroxyethyl} acetamide monohydrochloride". Page/Page column 3. . Retrieved 2008/06/13.