O-(2-Phenoxyethyl)hydroxylamine hydrochloride

Base Information

• Chemical Name: O-(2-Phenoxyethyl)hydroxylamine hydrochloride
• CAS No.: 5397-72-8
• Molecular Formula: C₈H₁₁NO₂*ClH
• Molecular Weight: 189.642
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID30968785
• NSC Number: 4253
• Mol file: 5397-72-8.mol

Synonyms:5397-72-8;O-(2-Phenoxyethyl)hydroxylamine hydrochloride;1-[2-(ammoniooxy)ethoxy]benzene chloride;O-(2-phenoxyethyl)hydroxylamine;hydrochloride;MFCD01114593;1-[2-(Aminooxy)ethoxy]benzene hydrochloride;Hydroxylamine, O-(2-phenoxyethyl)-, hydrochloride;SCHEMBL1715403;METHYL2-HYDROXYEICOSANOATE;DTXSID30968785;NSC4253;OVSNPPTZTPXOLP-UHFFFAOYSA-N;NSC-4253;AKOS005070255;AT21707;SY006322;O-(2-PHENOXYETHYL)HYDROXYLAMINE HCL;O-(2-Phenoxyethyl)hydroxylaminehydrochloride;CS-0322958;FT-0680275;3F-936;J-523793;1-[2-(ammoniooxy)ethoxy]benzene chloride, AldrichCPR;O-(2-Phenoxyethyl)hydroxylamine--hydrogen chloride (1/1)

Chemical Property of O-(2-Phenoxyethyl)hydroxylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000258mmHg at 25°C
• Melting Point: 182-188°C
• Boiling Point: 286.7°Cat760mmHg
• Flash Point: 144.4°C
• PSA: 44.48000
• Density: 1.094g/cm³
• LogP: 2.45800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 189.0556563
• Heavy Atom Count: 12
• Complexity: 92.1

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(aminooxy)ethoxy]benzenehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCON.Cl

Technology Process of O-(2-Phenoxyethyl)hydroxylamine hydrochloride

There total 2 articles about O-(2-Phenoxyethyl)hydroxylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-phenoxyethoxy)phthalimide (338406-38-5) → O-(2-phenoxy-ethyl)-hydroxylamine; hydrochloride (5397-72-8)

Guidance literature:

N-(2-phenoxyethoxy)phthalimide; With hydrazine hydrate;

With hydrogenchloride; In water;

DOI:10.1021/jm500367e

Reference yield:

phenoxyethyl bromide (589-10-6) → O-(2-phenoxy-ethyl)-hydroxylamine; hydrochloride (5397-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 100 °C

2: hydrazine hydrate

With hydrazine hydrate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm500367e

Reference yield: 82.0%

O-(2-phenoxy-ethyl)-hydroxylamine; hydrochloride (5397-72-8) + CYTIDINE (65-46-3) → C17H21N3O7 (1597430-53-9)

Guidance literature:

With pyridine; at 100 ℃;

DOI:10.1021/jm500367e

upstream raw materials:

N-(2-phenoxyethoxy)phthalimide

phenoxyethyl bromide

Downstream raw materials:

2-Phenoxy-ethoxyguanidin

C₁₇H₂₁N₃O₇

Refernces