2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

Base Information

• Chemical Name: 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
• CAS No.: 75679-58-2
• Molecular Formula: C17H18O5
• Molecular Weight: 302.327
• Mol file: 75679-58-2.mol

Synonyms:2',4'-Dihydroxy-4,6'-dimethoxydihydrochalcone;.2',4'-Dihydroxy-4,6'-dimethoxydihydrochalcone;.4′,6′-dihydroxy-2′,4-dimethoxydihydrochalcone;dimethoxydihydrochalcone2',4'-Dihydroxy-4,6'-;2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone;1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one;.2',4'-dihydroxy-4',6'-dimethoxydihydrochalcone;

Chemical Property of 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

Chemical Property:

• Vapor Pressure: 9.24E-11mmHg at 25°C
• Melting Point: 169-170 °C(Solv: dichloromethane (75-09-2); methanol (67-56-1))
• Boiling Point: 503.5°Cat760mmHg
• PKA: 7.31±0.40(Predicted)
• Flash Point: 184.7°C
• PSA: 75.99000
• Density: 1.243g/cm³
• LogP: 2.93050

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

There total 11 articles about 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C21H26O7 → 2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone (75679-58-2)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; dichloromethane; at 60 ℃; for 1h;

DOI:10.1016/j.bcp.2021.114825

Reference yield: 70.0%

2′,4′-dihydroxy-4,6′-dimethoxychalcone (855740-21-5) → 2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone (75679-58-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr; Schlenk technique; Sealed tube;

DOI:10.1039/c3gc41403e

Reference yield: 40.2%

(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one (56121-44-9) → 2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone (75679-58-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1.5h; under 12929 Torr;

DOI:10.1021/jm800812k

upstream raw materials:

(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

5-methoxyresorcinol

3-(4-methoxyphenyl)propionitrile

1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one

Downstream raw materials:

2',4'-diacetoxy-4,6'-dimethoxydihydrochalkone

2'-hydroxy-4,4',6'-trimethoxydihydrochalcone

2'-acetoxy-4,4',6'-trimethoxydihydrochalkone

Refernces

• 1、 Wei, Yu,Tang, Jinghua,Cong, Xuefeng,Zeng, Xiaoming. "Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction". . p. 3165 - 3169. Retrieved 2013/11/06.
• 2、 Aponte, José C.,Verástegui, Manuela,Málaga, Edith,Zimic, Mirko,Quiliano, Miguel,Vaisberg, Abraham J.,Gilman, Robert H.,Hammond, Gerald B.. "Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones". experimental part. p. 6230 - 6234. Retrieved 2009/09/25.