Bis(p-methoxyphenyl)iodonium bromide

Base Information

• Chemical Name: Bis(p-methoxyphenyl)iodonium bromide
• CAS No.: 19231-06-2
• Molecular Formula: C14H14BrIO2
• Molecular Weight: 421.072
• Hs Code.: 2909309090
• European Community (EC) Number: 242-899-4
• DSSTox Substance ID: DTXSID80940894
• Mol file: 19231-06-2.mol

Synonyms:19231-06-2;Bis(p-methoxyphenyl)iodonium bromide;Bis(4-methoxyphenyl)iodonium bromide;Di(p-anisyl)iodonium Bromide;bis(4-methoxyphenyl)iodanium;bromide;Iodonium, bis(4-methoxyphenyl)-, bromide;EINECS 242-899-4;bis(4-methoxyphenyl)iodanium bromide;C14H14BrIO2;C14H14IO2.Br;SCHEMBL8745388;C14-H14-I-O2.Br;DTXSID80940894;Bis(4-methoxyphenyl)iodoniumbromide;MFCD00031571;AKOS024431193;Bis(4-Methoxy Phenyl)Iodonium Bromide;s11873;AS-10705;Iodonium,bis(4-methoxyphenyl)-,bromide(1:1);Bis(4-Methoxyphenyl)-Iodonium Bromide (1:1);A853768;Iodonium, bis(4-methoxyphenyl)-, bromide (1:1)

Chemical Property of Bis(p-methoxyphenyl)iodonium bromide

Chemical Property:

• Vapor Pressure: 0Pa at 20℃
• Melting Point: 190-192 °C
• PSA: 18.46000
• Density: 1.82[at 20℃]
• LogP: -3.16380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: 2.3mg/L at 20℃
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 419.92219
• Heavy Atom Count: 18
• Complexity: 184

Purity/Quality:

99.9% ^*data from raw suppliers

Di(p-anisyl)iodoniumBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)[I+]C2=CC=C(C=C2)OC.[Br-]
• Uses: bis(p-methoxyphenyl)iodonium bromide is a diphenyliodonium compound. In vitro fermentation studies have showed that diphenyliodonium compounds are inhibitors of amino acid utilization. Di(p-anisyl)iodonium Br omide is used as a reactant in the preparation of Thyroid hormone analogs and analogs of clofibrate and clobuzarit. Di(p-anisyl)iodonium Bromide is a diphenyliodonium compound. In vitro fermentation studies have showed that diphenyliodonium compounds are inhibitors of amino acid utilization. Di(p-anisyl)iodonium Bromide is used as a reactant in the preparation of Thyroid hormone analogs and analogs of clofibrate and clobuzarit.

Technology Process of Bis(p-methoxyphenyl)iodonium bromide

There total 2 articles about Bis(p-methoxyphenyl)iodonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxybenzene (100-66-3) → 4,4'-dimethoxy-diphenyliodonium bromide (19231-06-2)

Guidance literature:

With iodosyl sulfate; acetic acid; anschliessend Behandeln mit wss. Natriumbromid-Loesung;

Reference yield:

para-iodoanisole (696-62-8) + methoxybenzene (100-66-3) → 4,4'-dimethoxy-diphenyliodonium bromide (19231-06-2)

Guidance literature:

para-iodoanisole; With sodium perborate; acetic anhydride; at 40 ℃; for 1.5h;

methoxybenzene; With sulfuric acid; at 15 ℃; for 5h;

With potassium bromide;

DOI:10.3390/61100875

Reference yield: 100.0%

4,4'-dimethoxy-diphenyliodonium bromide (19231-06-2) → 1-bromo-4-methoxy-benzene (104-92-7)

Guidance literature:

In benzene-d6; at 120 ℃; for 5h; Sealed tube;

upstream raw materials:

methoxybenzene

para-iodoanisole

Downstream raw materials:

N-acetyl-O-(4-methoxyphenyl)-3,5-diiodo-L-tyrosine ethyl ester

1-bromo-4-methoxy-benzene

para-iodoanisole

3,3,3-Trifluoro-2-(4-methoxy-phenoxy)-2-trifluoromethyl-propionic acid ethyl ester

Refernces

• 1、 Kryska, Anna,Skulski, Lech. "One-pot preparations of diaryliodonium bromides from iodoarenes and arenes, with sodium perborate as the oxidant". . p. 875 - 880. Retrieved 2007/10/03.