8,8'-Biquinoline

Base Information

• Chemical Name: 8,8'-Biquinoline
• CAS No.: 60021-28-5
• Molecular Formula: C18H12N2
• Molecular Weight: 256.307
• Mol file: 60021-28-5.mol

Synonyms:8,8‘-Biquinoline;8,8'-biquinoline;8,8'-biquinolyl;8,8'-bisquinolyl;[8,8']Bichinolyl;8,8'-Bichinolin;[8,8']biquinolinyl;

Chemical Property of 8,8'-Biquinoline

Chemical Property:

• Melting Point: 210-211 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 423.6±30.0 °C(Predicted)
• PSA: 25.78000
• Density: 1.223±0.06 g/cm3(Predicted)
• LogP: 4.45000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8,8'-Biquinoline

There total 4 articles about 8,8'-Biquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

8-quinolylgold(I) → 8,8′-biquinoline (60021-28-5) + gold (7440-57-5,457905-15-6)

Guidance literature:

In neat (no solvent); pyrolysis of Au complex at 210°C, 0,2 mm Hg;

DOI:10.1016/S0022-328X(00)85924-0

Reference yield: 61.0%

1,3-Benzothiazole (95-16-9) + 8-bromoquinoline (16567-18-3) → quinoline (91-22-5) + 8,8′-biquinoline (60021-28-5) + 2-(quinolin-8-yl)benzo[d]thiazole (1301758-98-4)

Guidance literature:

With PdCl(1,4-bis(diphenylphosphino)butane)(C₃H₅); caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 24h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1039/c3cy00150d

Reference yield: 22.0%

8-quinolinylboronic acid (86-58-8) + triphenylphosphine (603-35-0) → 8-phenylquinoline (605-04-9) + 8,8′-biquinoline (60021-28-5)

Guidance literature:

With sodium acetate; In acetonitrile; at 35 ℃; for 24h; Solvent; Reagent/catalyst; Temperature; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.poly.2021.115550

upstream raw materials:

1,3-Benzothiazole

8-bromoquinoline

8-quinolinylboronic acid

triphenylphosphine

Refernces

• 1、 Laroche, Jenny,Beydoun, Kassem,Guerchais, Veronique,Doucet, Henri. "Direct heteroarylation of 5-bromothiophen-2-ylpyridine and of 8-bromoquinoline via palladium-catalysed C-H bond activation: Simpler access to heteroarylated nitrogen-based derivatives". . p. 2072 - 2080. Retrieved 2013/07/26.