4-METHOXY-3-METHYLPHENYLACETIC ACID

Base Information

• Chemical Name: 4-METHOXY-3-METHYLPHENYLACETIC ACID
• CAS No.: 4513-73-9
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2918990090
• Mol file: 4513-73-9.mol

Synonyms:Aceticacid, (4-methoxy-m-tolyl)- (7CI,8CI);2-(4-Methoxy-3-methylphenyl)acetic acid;3-Methyl-4-methoxyphenylacetic acid;4-Methoxy-3-methylbenzeneacetic acid;4-Methoxy-3-methylphenylacetic acid;

Chemical Property of 4-METHOXY-3-METHYLPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000212mmHg at 25°C
• Melting Point: 93 °C
• Refractive Index: 1.534
• Boiling Point: 313.4 °C at 760 mmHg
• PKA: 4.45±0.10(Predicted)
• Flash Point: 123.4 °C
• PSA: 46.53000
• Density: 1.146 g/cm³
• LogP: 1.63070

Purity/Quality:

99%, ^*data from raw suppliers

4-Methoxy-3-methylphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-3-METHYLPHENYLACETIC ACID

There total 14 articles about 4-METHOXY-3-METHYLPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylmethoxybenzene (578-58-5) → 2-(4-methoxy-3-methylphenyl)acetic acid (4513-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 57.2 percent / trifluoroacetic acid / 3 h

2: 84.6 percent / Triton-B / methanol; dioxane / 4 h / 80 °C

3: 1.) hydrogen chloride, 2.) NaOH / 1.) ethanol, ice-salt cooling, 30 min, 2.) ethanol, reflux, 1 h

With hydrogenchloride; sodium hydroxide; N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; methanol; trifluoroacetic acid;

DOI:10.1248/cpb.30.2440

Reference yield:

2-diazo-1-(4-methoxy-3-methyl-phenyl)-ethanone → 2-(4-methoxy-3-methylphenyl)acetic acid (4513-73-9)

Guidance literature:

With silver(l) oxide; In 1,4-dioxane;

DOI:10.1016/S0960-894X(00)00318-8

Reference yield:

4-methoxy-3-methylbenzoic acid (6880-04-2) → 2-(4-methoxy-3-methylphenyl)acetic acid (4513-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂

2: diethyl ether / 0 °C

3: aq. Ag₂O / dioxane

With oxalyl dichloride; N,N-dimethyl-formamide; silver(l) oxide; In 1,4-dioxane; diethyl ether; dichloromethane; 1: Chlorination / 2: Substitution / 3: Rearrangement;

DOI:10.1016/S0960-894X(00)00318-8

upstream raw materials:

2-(4-methoxy-3-methylphenyl)acetonitrile

ethyl 2-(4-methoxy-3-methylphenyl)-2-oxoacetate

(4-hydroxy-3-methylphenyl)acetic acid

dimethyl sulfate

Downstream raw materials:

methyl 2-(4-methoxy-3-methylphenyl)acetate

[3-({tert-butoxycarbonyl-[2-(2-fluoro-phenyl)-ethyl]-amino}-methyl)-4-methoxy-phenyl]-acetic acid methyl ester

[2-(2-fluoro-phenyl)-ethyl]-[5-(2-hydroxy-ethyl)-2-methoxy-benzyl]-carbamic acid tert-butyl ester

(3-{[2-(2-fluoro-phenyl)-ethylamino]-methyl}-4-methoxy-phenyl)-acetic acid methyl ester

Refernces

• 1、 Katagiri,Kato,Nakano. "Studies on ketene and its derivatives. CIX. Synthesis of naturally occurring anthracene-9,10-diones". . p. 2440 - 2446. Retrieved 2007/10/02.