3-(Piperidin-1-yl)propan-1-amine

Base Information

• Chemical Name: 3-(Piperidin-1-yl)propan-1-amine
• CAS No.: 3529-08-6
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 2933399090
• European Community (EC) Number: 222-557-0
• DSSTox Substance ID: DTXSID20188778
• Nikkaji Number: J216.176A
• Wikidata: Q72441325
• ChEMBL ID: CHEMBL161741
• Mol file: 3529-08-6.mol

Synonyms:3-(piperidin-1-yl)propan-1-amine;3529-08-6;1-(3-aminopropyl)piperidine;3-PIPERIDINOPROPYLAMINE;1-Piperidinepropanamine;3-Piperidin-1-yl-propylamine;3-piperidin-1-ylpropan-1-amine;3-piperidino-propylamine;3-(Piperidin-1-yl)propylamine;Piperidine-1-propylamine;3-Piperidin-1-ylpropylamine;N-(3-aminopropyl)piperidine;(3-Piperidin-1-ylpropyl)amine dihydrochloride;piperidinopropylamine;1-piperidinepropylamine;3-aminopropylpiperidine;1-piperidinepropaneamine;3-piperidino propylamine;N-3-aminopropylpiperidine;3-amino-propyl-piperidine;SCHEMBL40664;3-PIPERIDINEPROPYLAMINE;1-(3-aminopropyl) piperidine;3-piperidine-1-yl-propylamine;(3-piperidin-1-ylpropyl)amine;CHEMBL161741;N-(3'-aminopropyl)-piperidine;3-(piperidine-1-yl)propylamine;1-(3-Aminoprop-1-yl)piperidin;1-PIPERIDINEPROPANEDIAMINE;3-(piperidin-1-yl)-propylamine;DTXSID20188778;[3-(Piperidin-1-yl)]propylamine;3-(1-piperidinyl)-1-propanamine;HMS1704L11;1-amino-3-(piperidin-1-yl)propane;EINECS 222-557-0;N-(3-Aminopropyl)piperidine, 95%;AM9934;MFCD00023784;STK500334;3-(piperidin-1-yl) propane-1-amine;AKOS000113659;LF-0523;SB41100;126553-14-8;BB 0255096;CS-0105129;FT-0629169;EN300-13955;(+/-)-1-AMINO-3-N-(4-BOC-PIPERAZINYL)-2-PROPANOL

Chemical Property of 3-(Piperidin-1-yl)propan-1-amine

Chemical Property:

• Refractive Index: 1.476
• Boiling Point: 215 °C at 760 mmHg
• PKA: 10.44±0.10(Predicted)
• Flash Point: 77.9 °C
• PSA: 29.26000
• Density: 0.916 g/cm³
• LogP: 1.45930
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 142.146998583
• Heavy Atom Count: 10
• Complexity: 77.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Piperidin-1-yl)propylamine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C;Xi
• Hazard Codes: C,Xi
• Statements: 10-34-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCCN
• Uses: Reactant for synthesis of:A chemotype that inhibits Botulinum neurotoxin serotype A light chain, P. falciparum Malaria, and Ebola filovirusMembrane targeting antibiotics5-HT3A receptor antagonistsHistamine H3 antagonistsBerberine derivatives for stabilization of G-quadruplex DNA and down regulation of oncogene c-mycReactant for incorporation of basic side chains into cryptolepine scaffold for antimalarial activity

Technology Process of 3-(Piperidin-1-yl)propan-1-amine

There total 18 articles about 3-(Piperidin-1-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(3-(piperidin-1-yl)-propyl)isoindoline-1,3-dione (4733-45-3) → 1-(3-aminopropyl)piperidine (3529-08-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2019.01.052

Reference yield: 70.0%

3-(piperidin-1-yl)propionitrile (3088-41-3) → 1-(3-aminopropyl)piperidine (3529-08-6)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol;

DOI:10.1016/S0960-894X(97)00087-5

Reference yield: 55.0%

→ 1-(3-aminopropyl)piperidine (3529-08-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

upstream raw materials:

piperidine

2-(3-bromopropyl)isoindole-1,3-dione

3-(piperidin-1-yl)propionitrile

butan-1-ol

Downstream raw materials:

2-methyl-3-(3-piperidin-1-yl-propyl)-3H-quinazolin-4-one

2,5-bis-(3-piperidino-propylamino)-[1,4]benzoquinone

2-nitro-N-(3-piperidino-propyl)-aniline

N-mesityl-N'-(3-piperidino-propyl)-urea

Refernces

• 1、 Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale. "New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis". . p. 304 - 317. Retrieved 2019/02/07.
• 2、 Zhang, Jun,Shen, Weiyi,Li, Xiaoning,Chai, Yun,Li, Senjun,Lv, Kai,Guo, Huiyuan,Liu, Mingliang. "Synthesis and antitumor activity of 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety". . . Retrieved 2016/12/30.