Technology Process of Benzoic acid,
4-[(7S)-5,6,7,8-tetrahydro-7-[[(phenylmethoxy)carbonyl]amino]-2-naphth
alenyl]-, methyl ester
There total 8 articles about Benzoic acid,
4-[(7S)-5,6,7,8-tetrahydro-7-[[(phenylmethoxy)carbonyl]amino]-2-naphth
alenyl]-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
water;
at 20 - 80 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jm800222k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h
3: sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C / pH 7 - 8
4: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere
With
2,6-dimethylpyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen; boron tribromide; sodium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water;
5: Suzuki coupling;
DOI:10.1021/jm800222k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 2 h
2: sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C / pH 7 - 8
3: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere
With
2,6-dimethylpyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen; sodium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water;
4: Suzuki coupling;
DOI:10.1021/jm800222k
