Dihydromollugin

Base Information

• Chemical Name: Dihydromollugin
• CAS No.: 60657-93-4
• Molecular Formula: C17H18O4
• Molecular Weight: 286.32
• Mol file: 60657-93-4.mol

Synonyms:

Chemical Property of Dihydromollugin

Chemical Property:

• Melting Point: 96-97 °C
• Boiling Point: 448.2±45.0 °C(Predicted)
• PKA: 8.59±0.40(Predicted)
• Density: 1.212±0.06 g/cm3(Predicted)

Purity/Quality:

≥98% ^*data from raw suppliers

Dihydromollugin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dihydromollugin

There total 18 articles about Dihydromollugin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

mollugin (55481-88-4) → methyl 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo-[h]chromene-5-carboxylate (60657-93-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 5h; under 1034.32 Torr; Inert atmosphere;

DOI:10.1016/j.bioorg.2013.11.008

Reference yield: 54.0%

2-methyl-3-buten-2-ol (115-18-4) + methyl 1,4-dihydroxy-2-naphthoate (77060-74-3) → methyl 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo-[h]chromene-5-carboxylate (60657-93-4)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1002/jccs.200100014

Reference yield: 54.0%

methyl 1,4-dihydroxy-2-naphthoate (77060-74-3) + isoprene (78-79-5,9003-31-0) → methyl 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo-[h]chromene-5-carboxylate (60657-93-4)

Guidance literature:

With o-tetrachloroquinone; tricarbonylcyclopentadienylmolybdenum(II) chloride; In chlorobenzene; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ol802800s

upstream raw materials:

mollugin

2-methyl-3-buten-2-ol

methyl 1,4-dihydroxy-2-naphthoate

methyl 1,4-dihydroxy-3-(3-methylbut-2-enyl)-naphthalene-2-carboxylate

Downstream raw materials:

mollugin

Refernces

• 1、 -. "Mollugin derivatives, optical isomer thereof, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition for preventing or treating inflammatory bowel disease comprising the same as an active ingredient". Paragraph 0071; 0073; 0076; 0202-0204. . Retrieved 2017/12/15.
• 2、 Idhayadhulla, Akber,Xia, Likai,Lee, Yong Rok,Kim, Sung Hong,Wee, Young-Jung,Lee, Chong-Soon. "Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities". . p. 77 - 82. Retrieved 2014/01/17.