3,5-BIS(TRIFLUOROMETHYL)TOLUENE

Base Information

• Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)TOLUENE
• CAS No.: 75462-61-2
• Molecular Formula: C9H6F6
• Molecular Weight: 228.137
• Hs Code.: 2903999090
• Mol file: 75462-61-2.mol

Synonyms:1-Methyl-3,5-bis(trifluoromethyl)benzene;3,5-Bis(trifluoromethyl)toluene;

Chemical Property of 3,5-BIS(TRIFLUOROMETHYL)TOLUENE

Chemical Property:

• Boiling Point: 125.9 °C at 760 mmHg
• Flash Point: 29.3 °C
• PSA: 0.00000
• Density: 1.32 g/cm³
• LogP: 4.03260

Purity/Quality:

99% ^*data from raw suppliers

3,5-Bis(trifluoromethyl)toluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-BIS(TRIFLUOROMETHYL)TOLUENE

There total 7 articles about 3,5-BIS(TRIFLUOROMETHYL)TOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C22H20F6N2O4 (1448041-81-3) → phenylmethyl 1-piperazinecarboxylate (31166-44-6) + 3,5-bis(trifluoromethyl)benzylchloride (75462-61-2)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41642a

Reference yield: 99.0%

C19H22F6N2O4 (1448041-79-9) → 3,5-bis(trifluoromethyl)benzylchloride (75462-61-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc41642a

Reference yield: 99.0%

C21H29F6NO3Si (1448041-78-8) → 4-(tert-butyldimethylsilyloxy)piperidine (97231-91-9) + 3,5-bis(trifluoromethyl)benzylchloride (75462-61-2)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc41642a

upstream raw materials:

3,5-bis(trifluoromethyl)benzenemethanol

C₂₀H₂₁F₆NO₂

C₂₁H₂₉F₆NO₃Si

C₁₉H₂₂F₆N₂O₄

Downstream raw materials:

3-(3,5-bis(trifluoromethyl)phenyl)propanal

2-((3,5-bis(trifluoromethyl)benzyl)thio)benzo[d]thiazole

3,5-bistrifluoromethylbenzoic acid

3,5-Bis(trifluoromethyl)benzaldehyde

Refernces

• 1、 Ankner, Tobias,Hilmersson, G?ran. "SmI2/H2O/amine promoted reductive cleavage of benzyl-heteroatom bonds: optimization and mechanism". experimental part. p. 10856 - 10862. Retrieved 2010/02/28.