5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL

Base Information

• Chemical Name: 5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL
• CAS No.: 613240-20-3
• Molecular Formula: C11H8F3NO2
• Molecular Weight: 243.185
• Mol file: 613240-20-3.mol

Synonyms:[5-(4-trifluoromethylphenyl)-isoxazole-3-yl] methyl alcohol;[5-(4-trifluoromethyl-phenyl)-isoxazole-3-yl]-methanol;[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-yl]-methanol;[5-(4-trifluoromethylphenyl) isoxazole-3-yl] methanol;[5-(4-trifluoromethylphenyl)isoxazole-3-yl]methanol;

Chemical Property of 5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL

Chemical Property:

• Melting Point: 111 - 113 °C
• Boiling Point: 343.6±37.0 °C(Predicted)
• PKA: 12.94±0.10(Predicted)
• PSA: 46.26000
• Density: 1.365±0.06 g/cm3(Predicted)
• LogP: 2.85270

Purity/Quality:

5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL

There total 5 articles about 5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ {5-[4-(trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol (613240-20-3)

Guidance literature:

Reference yield: 96.0%

5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester (613240-18-9) → {5-[4-(trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol (613240-20-3)

Guidance literature:

5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2.08333h;

With hydrogenchloride; In methanol; water; at 10 ℃;

Reference yield: 55.0%

methyl 5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate → {5-[4-(trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol (613240-20-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 50 ℃; for 5h;

DOI:10.1016/j.ejmech.2019.111635

upstream raw materials:

5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester

methyl 2,4-dioxo-4-(4-(trifluoromethyl)phenyl)butanoate

1-(4-trifluoromethylphenyl)ethanone

Downstream raw materials:

3-(chloromethyl)-5-[4-(trifluoromethyl)phenyl]isoxazole

3-methoxymethoxymethyl-5-(4-trifluoromethyl-phenyl)isoxazole

3-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole

methanesulfonic acid 5-(4-trifluoromethyl-phenyl)-isoxazol-3-ylmethyl ester

Refernces

• 1、 Shen, Lan,Zhang, Yan,Wang, Aihua,Sieber-McMaster, Ellen,Chen, Xiaoli,Pelton, Patricia,Xu, June Z.,Yang, Maria,Zhu, Peifang,Zhou, Lubing,Reuman, Michael,Hu, Zhiyong,Russell, Ronald,Gibbs, Alan C.,Ross, Hamish,Demarest, Keith,Murray, William V.,Kuo, Gee-Hong. "Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists". . p. 3321 - 3341. Retrieved 2008/09/19.
• 2、 -. "BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL". Page/Page column 35-36. . Retrieved 2008/06/13.