6-Hydroxyindazole

Base Information

• Chemical Name: 6-Hydroxyindazole
• CAS No.: 23244-88-4
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.137
• Hs Code.: 2933990090
• Mol file: 23244-88-4.mol

Synonyms:6-Hydroxyindazole;Indazol-6-ol;NSC 92744;

Chemical Property of 6-Hydroxyindazole

Chemical Property:

• Appearance/Colour: light brown powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 157-160 °C
• Refractive Index: 1.76
• Boiling Point: 366.518 °C at 760 mmHg
• PKA: 9.17±0.40(Predicted)
• Flash Point: 175.464 °C
• PSA: 48.91000
• Density: 1.434 g/cm³
• LogP: 1.26850
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-Indazol-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 36/37/38:
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26-36:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxyindazole

There total 9 articles about 6-Hydroxyindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1H-indazol-6-yl)boronic acid (885068-10-0) → 1H-indazol-6-ol (23244-88-4)

Guidance literature:

With water; caesium carbonate; hydrazine hydrate; at 80 ℃; for 12h;

DOI:10.1039/c4ra05589f

Reference yield: 87.0%

6-amino-1H-indazole (6967-12-0) → 1H-indazol-6-ol (23244-88-4)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 0 - 120 ℃;

DOI:10.1016/j.bmc.2015.09.048

Reference yield: 86.0%

6-methoxy-1H-indazole (3522-07-4) → 1H-indazol-6-ol (23244-88-4)

Guidance literature:

With hydrogen iodide; for 4h; Reflux;

upstream raw materials:

6-amino-1H-indazole

6-nitroindazole

2-methyl-5-nitroaniline

2-fluoro-4-methoxy-benzaldehyde

Downstream raw materials:

6-((tert-butyldiphenylsilyl)oxy)-3-iodo-1H-indazole

tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-iodo-1H-indazole-1-carboxylate

tert-butyl 6-hydroxy-3-phenyl-1H-indazole-1-carboxylate

3-bromo-6-hydroxyl-1H-indazole

Refernces

• 1、 -. "A catalytic oxidation fragrant boron class compound preparing phenol method (by machine translation)". Paragraph 0073; 0097; 0098. . Retrieved 2017/08/08.
• 2、 -. "Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia". Page/Page column 31. . Retrieved 2018/12/01.