Technology Process of 5-(1-Hydroxytridecyl)oxolan-2-one
There total 1 articles about 5-(1-Hydroxytridecyl)oxolan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: 98 percent / MnO2 / hexane / 24 h / 20 °C
2: 93 percent / 18-crown-6; t-BuOK / tetrahydrofuran / 2.5 h / -78 °C
3: 86 percent / OsO4; MeSO2NH2; (DHQD)2PHAL / K3Fe(CN)6; K2CO3 / 2-methyl-propan-2-ol; H2O / 0 °C
4: 98 percent / H2 / Pd/C / methanol / 24 h / 760 Torr
With
manganese(IV) oxide; osmium(VIII) oxide; 18-crown-6 ether; methanesulfonamide; potassium tert-butylate; hydrogen; 1,4-bis(9-O-dihydroquinidine)phthalazine;
palladium on activated charcoal; potassium carbonate; potassium hexacyanoferrate(III);
In
tetrahydrofuran; methanol; hexane; water; tert-butyl alcohol;
2: Still-Gennari reaction / 3: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo061057s
- Guidance literature:
-
Multi-step reaction with 19 steps
1: i-Pr2NEt / CH2Cl2
2: DIBAL / CH2Cl2
3: 76 percent / NaH / tetrahydrofuran / -78 °C
4: PPTS / CH2Cl2
5: AD-mix α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O
6: PPTS / CH2Cl2
7: LiAlH4 / diethyl ether
8: pyridine
9: PPTS / methanol
10: KOH
11: 98 percent / PPTS / CH2Cl2
12: 96 percent / BF3*Et2O / tetrahydrofuran
13: i-Pr2NEt / CH2Cl2
14: PPTS / methanol
15: 53 percent / CuI, pyrrolidine / Pd(Ph3P)4
16: 77 percent / H2 / Rh(Ph3P)3Cl / benzene
17: Et3N / CH2Cl2
18: HCl / methanol
19: KOH / tetrahydrofuran
With
pyrrolidine; pyridine; hydrogenchloride; potassium hydroxide; AD-mix-α; copper(l) iodide; lithium aluminium tetrahydride; methanesulfonamide; boron trifluoride diethyl etherate; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
Wilkinson's catalyst; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1016/0040-4039(96)01086-6
