1,4-Cyclohexadiene-1-carboxylic acid, 3,6-dioxo-, ethyl ester

Base Information

• Chemical Name: 1,4-Cyclohexadiene-1-carboxylic acid, 3,6-dioxo-, ethyl ester
• CAS No.: 62830-98-2
• Molecular Formula: C9H8O4
• Molecular Weight: 180.16
• Mol file: 62830-98-2.mol

Synonyms:

Chemical Property of 1,4-Cyclohexadiene-1-carboxylic acid, 3,6-dioxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-Cyclohexadiene-1-carboxylic acid, 3,6-dioxo-, ethyl ester

There total 6 articles about 1,4-Cyclohexadiene-1-carboxylic acid, 3,6-dioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2,5-dihydroxybenzoate (3943-91-7) → 2-ethoxycarbonyl-1,4-benzoquinone (62830-98-2)

Guidance literature:

With magnesium sulfate; silver(l) oxide; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.5b10152

Reference yield: 96.0%

→ 2-ethoxycarbonyl-1,4-benzoquinone (62830-98-2)

Guidance literature:

With magnesium sulfate; silver(l) oxide; In diethyl ether; at 25 ℃; for 1.5h;

Reference yield:

2,5-dimethoxybenzoic acid (2785-98-0) → 2-ethoxycarbonyl-1,4-benzoquinone (62830-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide

2: sulfuric acid

3: silver(I) oxide; magnesium(II) sulfate / diethyl ether / 2.5 h / 20 °C / Inert atmosphere

With sulfuric acid; boron tribromide; magnesium(II) sulfate; silver(I) oxide; In diethyl ether;

DOI:10.1002/ejoc.202200087

upstream raw materials:

ethyl 2,5-dihydroxybenzoate

oxalic acid monoethyl ester

p-benzoquinone

benzene

Refernces

• 1、 Bojack, Guido,Brown, Ronald W.,Dittgen, Jan,Heinemann, Ines,Helmke, Hendrik,Hills, Martin J.,Hohmann, Sabine,Holstein, Philipp M.,Schmutzler, Dirk,Frackenpohl, Jens. "Synthesis and SAR of 2,3-Dihydro-1-benzofuran-4-carboxylates: Potent Salicylic Acid-Based Lead Structures against Plant Stress". . . Retrieved 2022/03/27.
• 2、 -. "Catalytic asymmetric synthesis of aryl diphenol the axis chiral is joint method". Paragraph 0049; 0050; 0051; 0052; 0053. . Retrieved 2017/10/31.