1-Methylbiguanide hydrochloride

Base Information

• Chemical Name: 1-Methylbiguanide hydrochloride
• CAS No.: 1674-62-0
• Molecular Formula: C3H10ClN5
• Molecular Weight: 151.599
• Hs Code.: 2925299000
• European Community (EC) Number: 641-638-5
• UNII: 08RV8937YJ
• DSSTox Substance ID: DTXSID20937324
• NSC Number: 210483
• Mol file: 1674-62-0.mol

Synonyms:1-Methylbiguanide hydrochloride;1674-62-0;1-Methylbiguanide monohydrochloride;1-(diaminomethylidene)-2-methylguanidine;hydrochloride;Imidodicarbonimidic diamide, N-methyl-, hydrochloride (1:1);NSC-210483;BIGUANIDE, 1-METHYL-, MONOHYDROCHLORIDE;08RV8937YJ;1-Methylbiguanide Hydrochloride;Metformin Hydrochloride Imp. E (EP) as Hydrochloride;Metformin Related Compound B as Hydrochloride;Metformin Hydrochloride Impurity E as Hydrochloride;Metformin Impurity E as Hydrochloride;SCHEMBL3192055;DTXSID20937324;1-Methylbiguanide (hydrochloride);NSC210483;AKOS030254945;AS-80521;N'-METHYLBIGUANIDE MONOHYDROCHLORIDE;CS-0133699;FT-0774730;E81648;1-(diaminomethylidene)-3-methylguanidine hydrochloride;1-carbamimidamido-N-methylmethanimidamide hydrochloride;1-CARBAMIMIDOYL-3-METHYLGUANIDINE HYDROCHLORIDE;N-Methyltriimidodicarbonic diamide--hydrogen chloride (1/1);IMIDODICARBONIMIDIC DIAMIDE, N-METHYL-, MONOHYDROCHLORIDE

Chemical Property of 1-Methylbiguanide hydrochloride

Chemical Property:

• Vapor Pressure: 0.00154mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 225 °C at 760 mmHg
• Flash Point: 89.9 °C
• PSA: 97.78000
• Density: 1.45 g/cm³
• LogP: 1.10720
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 151.0624730
• Heavy Atom Count: 9
• Complexity: 120

Purity/Quality:

99%, ^*data from raw suppliers

1-Methylbiguanide Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN=C(N)N=C(N)N.Cl
• Uses: 1-Methylbiguanide Hydrochloride (Metformin USP Related Compound B) is a compound similar to Metformin Hydrochloride (M258815), an oral hypogylcemic agent.

Technology Process of 1-Methylbiguanide hydrochloride

There total 1 articles about 1-Methylbiguanide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methylamine hydrochloride (593-51-1) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → N1-methyl biguanide hydrochloride (1674-62-0)

Guidance literature:

In butan-1-ol; for 15h; Reflux;

Reference yield:

N1-methyl biguanide hydrochloride (1674-62-0) → CYANAMID (420-04-2) + 1-methylguanidine (471-29-4) + guanidine hydrochloride (50-01-1) + methylcyanamide (4674-68-4)

Guidance literature:

bei der thermischen Zersetzung;

Reference yield:

methylamine hydrochloride (593-51-1) + N1-methyl biguanide hydrochloride (1674-62-0) → 1-methylguanidine (471-29-4) + guanidine nitrate (113-00-8)

Guidance literature:

beim Erhitzen;

upstream raw materials:

methylamine hydrochloride

N-Cyanoguanidine

Downstream raw materials:

1-methylguanidine

guanidine nitrate

CYANAMID

guanidine hydrochloride

Refernces