N-Ethyl-N-methylaniline

Base Information

• Chemical Name: N-Ethyl-N-methylaniline
• CAS No.: 613-97-8
• Molecular Formula: C9H13N
• Molecular Weight: 135.209
• Hs Code.: 2921420090
• European Community (EC) Number: 210-364-4
• NSC Number: 3832
• UNII: Y9PKC9G2DW
• DSSTox Substance ID: DTXSID2060628
• Nikkaji Number: J1.200.420F,J46.549F
• Wikidata: Q63398695
• Mol file: 613-97-8.mol

Synonyms:N-ethyl-N-methylaniline

Chemical Property of N-Ethyl-N-methylaniline

Chemical Property:

• Vapor Pressure: 0.27mmHg at 25°C
• Melting Point: -6.87°C (estimate)
• Refractive Index: 1.54
• Boiling Point: 204 °C at 760 mmHg
• PKA: 5.96±0.20(Predicted)
• Flash Point: 74.4 °C
• PSA: 3.24000
• Density: 0.939 g/cm³
• LogP: 2.14270
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 135.104799419
• Heavy Atom Count: 10
• Complexity: 84.7

Purity/Quality:

98%min ^*data from raw suppliers

N-Ethyl-N-methylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C)C1=CC=CC=C1

Technology Process of N-Ethyl-N-methylaniline

There total 71 articles about N-Ethyl-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-methyl-N-ethylaniline N-oxide (825-19-4) → N-methyl-N-ethylaniline (613-97-8)

Guidance literature:

With phenylboronic acid; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2017.01.051

Reference yield: 96.0%

carbon dioxide (124-38-9,18923-20-1) + N-ethyl-N-phenylamine (103-69-5) → N-methyl-N-ethylaniline (613-97-8)

Guidance literature:

With copper nanoparticles-decorated triazinetriamine derived porous organic polymer; polymethylhydrosiloxane; In acetonitrile; at 80 ℃; for 9.5h; under 760.051 Torr; Inert atmosphere;

DOI:10.1039/d0nj02798g

Reference yield: 94.0%

acetic acid (64-19-7,77671-22-8) + N-methylaniline (100-61-8) → N-methyl-N-ethylaniline (613-97-8)

Guidance literature:

With platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; phenylsilane; 1,2-bis-(diphenylphosphino)ethane; In dibutyl ether; at 20 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja5093612

upstream raw materials:

N-acetyl-N-methylaniline

N-methyl-N-ethylaniline N-oxide

sodium phenoxide

N-ethyl-N,N-dimethylanilinium iodide

Downstream raw materials:

ethyl-phenyl-carbamonitrile

indole

N-methyl-N-ethylaniline N-oxide

N-ethyl-N-methyl-4-nitrosoaniline

Refernces

• 1、 Chen, Gong,Arai, Kenta,Morisaki, Kazuhiro,Kawabata, Takeo,Ueda, Yoshihiro. "Dirhodium-Catalyzed Chemo-and Site-Selective C-H Amidation of N, N-Dialkylanilines". supporting information. p. 728 - 732. Retrieved 2021/01/18.
• 2、 Runemark, August,Zacharias, Savannah C.,Sundén, Henrik. "Visible-Light-Driven Stereoselective Annulation of Alkyl Anilines and Dibenzoylethylenes via Electron Donor-Acceptor Complexes". . p. 1901 - 1910. Retrieved 2021/02/05.