N-Cyclohexylhydroxylamine

Base Information

• Chemical Name: N-Cyclohexylhydroxylamine
• CAS No.: 2211-64-5
• Molecular Formula: C6H13 N O
• Molecular Weight: 115.175
• Hs Code.: 2928000090
• European Community (EC) Number: 218-650-0
• UNII: 722GHL96BJ
• DSSTox Substance ID: DTXSID90176627
• Nikkaji Number: J3.389H
• Wikidata: Q27266009
• Mol file: 2211-64-5.mol

Synonyms:N-hydroxycyclohexylamine

Chemical Property of N-Cyclohexylhydroxylamine

Chemical Property:

• Vapor Pressure: 0.0578mmHg at 25°C
• Melting Point: 139-140 °C(lit.)
• Refractive Index: 1.4690 (estimate)
• Boiling Point: 205.9°Cat760mmHg
• Flash Point: 97.9°C
• PSA: 32.26000
• Density: 1g/cm³
• LogP: 1.68880
• Storage Temp.: ?20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 59.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Cyclohexylhydroxylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NO
• Uses: N-Cyclohexylhydroxylamine is a reactant for:Aldehyde-catalyzed intermolecular hydroamination1? ;Condensation reactions2? ;Preparation of cyclin-dependent kinase inhibitors selective for multiple cyclin-dependent kinases for potential use as antitumor agents3? ;Preparation of hydroxyurea derivatives as small molecule bradykinin B1 receptor antagonists. Reactant for:Aldehyde-catalyzed intermolecular hydroaminationCondensation reactionsPreparation of cyclin-dependent kinase inhibitors selective for multiple cyclin-dependent kinases for potential use as antitumor agentsPreparation of hydroxyurea derivatives as small molecule bradykinin B1 receptor antagonists

Technology Process of N-Cyclohexylhydroxylamine

There total 18 articles about N-Cyclohexylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-cyclohexyl-O-benzoylhydroxylamine (1485-75-2) → N-cyclohexyl-hydroxylamine (2211-64-5)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1039/C8SC04996C

Reference yield: 91.0%

cyclohexanone-oxime (100-64-1) → N-cyclohexyl-hydroxylamine (2211-64-5)

Guidance literature:

With borane pyridine complex; In ethanol; at 5 ℃; for 0.5h;

Reference yield: 85.0%

1-nitrocyclohexene (2562-37-0) → N-cyclohexyl-hydroxylamine (2211-64-5)

Guidance literature:

With sodium tetrahydroborate; borane-THF; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)89059-1

upstream raw materials:

1-chloro-1-nitrocyclohexane

cyclohexanone

cyclohexylamine

1-nitrocyclohexane

Downstream raw materials:

(Z)-N-benzylidenecyclohexanamine oxide

cyclohexyl-ethylidene-amine oxide

N-butylidenecyclohexanamine N-oxide

cyclohexanone-oxime

Refernces

• 1、 Coutts,Mukherjee. "-". . p. 63. Retrieved 1970.
• 2、 Kandale, Ajit,Patel, Khushboo,Hussein, Waleed M.,Wun, Shun Jie,Zheng, Shan,Tan, Lendl,West, Nicholas P.,Schenk, Gerhard,Guddat, Luke W.,McGeary, Ross P.. "Analogues of the Herbicide, N-Hydroxy- N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads". . p. 1670 - 1684. Retrieved 2021/02/27.
• 3、 Banerjee, Amit,Yamamoto, Hisashi. "Direct N-O bond formation via oxidation of amines with benzoyl peroxide". . p. 2124 - 2129. Retrieved 2019/02/20.