Carboxypeptidase B

Base Information

• Chemical Name: Carboxypeptidase B
• CAS No.: 9025-24-5
• Molecular Formula: C31H38N4O7S
• Molecular Weight: 610.72102
• European Community (EC) Number: 232-788-9
• DSSTox Substance ID: DTXSID801009277
• Mol file: 9025-24-5.mol

Synonyms:Carboxypeptidase B;Procarboxypeptidase B;Protaminase

Chemical Property of Carboxypeptidase B

Chemical Property:

• Appearance/Colour: powder
• PSA: 197.75000
• LogP: 4.49790
• Storage Temp.: −20°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 15
• Exact Mass: 610.24612074
• Heavy Atom Count: 43
• Complexity: 997

Purity/Quality:

99% ^*data from raw suppliers

Carboxypeptidase?B from human pancreas 50-55?units/mgproteincarboxypeptidaseB ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,B,Xn
• Statements: 36-42-36/37/38
• Safety Statements: 26-36-36/37-24-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Enzymes
• Canonical SMILES: CC(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)SCC3=CC=CC=C3)NC(=O)CCC(=O)O
• Uses: The enzyme from Sigma has been used to develop homogeneous time-resolved fluorescence (HTRF) assay for measuring carboxypeptidase B activity in a miniaturized high-throughput screening format. It has been used to evaluate the impact of the C-terminal lysine(s) in human plasminogen binding to Bifidobacterium. The effect of treatment with carboxypeptidase B, which is a C-terminal lysine-specific endopeptidase, is measured using flow cytometry analysis. Carboxypeptidase B from Sigma has been used as a reference for assaying carboxypeptidase activity in lysed pituitary granules derived from the anterior and intermediate lobes of rat. The enzyme has also been used to digest plasma samples by removing C-terminal basic amino acids, to get a distinct band for each allotype during C4 electrophoresis.