3,5-Dibromo-2-fluoro-6-methylpyridine

Base Information

• Chemical Name: 3,5-Dibromo-2-fluoro-6-methylpyridine
• CAS No.: 632628-07-0
• Molecular Formula: C6H4Br2FN
• Molecular Weight: 268.90900
• Hs Code.: 2933399090
• Mol file: 632628-07-0.mol

Synonyms:PC7208;

Chemical Property of 3,5-Dibromo-2-fluoro-6-methylpyridine

Chemical Property:

• Boiling Point: 233℃
• Flash Point: 95℃
• PSA: 12.89000
• Density: 1.984
• LogP: 3.05410
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dibromo-2-fluoro-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dibromo-2-fluoro-6-methylpyridine

There total 1 articles about 3,5-Dibromo-2-fluoro-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-3,5-dibromo-6-methylpyridine (91872-10-5) → 3,5-dibromo-2-fluoro-6-methylpyridine (632628-07-0)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; at 0 - 60 ℃; for 9h;

Reference yield:

3,5-dibromo-2-fluoro-6-methylpyridine (632628-07-0) → C6H3Br3FN (632628-08-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); dibenzoyl peroxide; In tetrachloromethane; for 12h; Heating / reflux;

upstream raw materials:

2-amino-3,5-dibromo-6-methylpyridine

Downstream raw materials:

C₆H₃Br₃FN

Refernces

• 1、 -. "(HALO-BENZO CARBONYL)HETEROBICYCLIC P38 KINASE INHIBITING AGENTS". Page 26-27. . Retrieved 2008/06/13.