4-(Diphenylmethyl)pyridine

Base Information

• Chemical Name: 4-(Diphenylmethyl)pyridine
• CAS No.: 3678-72-6
• Molecular Formula: C18H15 N
• Molecular Weight: 245.324
• Hs Code.: 2933399090
• European Community (EC) Number: 222-955-4
• NSC Number: 60655
• DSSTox Substance ID: DTXSID3063128
• Nikkaji Number: J205.592I
• Wikidata: Q81990505
• Pharos Ligand ID: 8YC2CD5JNCAM
• ChEMBL ID: CHEMBL150045
• Mol file: 3678-72-6.mol

Synonyms:4-Benzhydrylpyridine;4-(Diphenylmethyl)pyridine;3678-72-6;Diphenyl-4-pyridylmethane;4-Diphenylmethylpyridine;4-Benzhydryl-pyridine;Pyridine, 4-(diphenylmethyl)-;MLS002693296;CHEMBL150045;EINECS 222-955-4;NSC 60655;NSC60655;4-Benzhydrylpyridine #;4-diphenylmethyl pyridine;SCHEMBL733008;DTXSID3063128;Diphenyl-4-pyridylmethane, 99%;HMS3089N20;BDBM50123257;NSC-60655;AKOS015889254;NCI60_004677;SMR001559253;FT-0634958

Chemical Property of 4-(Diphenylmethyl)pyridine

Chemical Property:

• Vapor Pressure: 1.39E-05mmHg at 25°C
• Melting Point: 124-126 °C(lit.)
• Boiling Point: 378.2°Cat760mmHg
• PKA: 5.54±0.10(Predicted)
• Flash Point: 163.8°C
• PSA: 12.89000
• Density: 1.085g/cm³
• LogP: 4.26180
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 245.120449483
• Heavy Atom Count: 19
• Complexity: 226

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diphenyl-4-pyridylmethane 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C3=CC=NC=C3

Technology Process of 4-(Diphenylmethyl)pyridine

There total 16 articles about 4-(Diphenylmethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diphenyl(pyridin-4-yl)methanol (1620-30-0) → diphenyl-4-pyridylmethane (3678-72-6)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1080/00304940209356774

Reference yield: 93.0%

pyridine-4-carbaldehyde (872-85-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → diphenyl-4-pyridylmethane (3678-72-6)

Guidance literature:

With trifluorormethanesulfonic acid; for 6h;

DOI:10.1016/j.tet.2006.04.022

Reference yield: 92.0%

4-benzyl pyridine (2116-65-6) + chlorobenzene (108-90-7) → triphenyl(4-pyridyl)methane (95957-93-0) + diphenyl-4-pyridylmethane (3678-72-6)

Guidance literature:

With cesium hydroxide; tricyclohexylphosphine; di(acetonitrile)dichloropalladium; In toluene; xylene; for 14h; Heating;

DOI:10.1021/ol0708119

upstream raw materials:

4-Chloropyridine

Diphenylacetonitrile

diphenyl(pyridin-4-yl)methanol

benzophenone

Downstream raw materials:

2,2-diphenyl-2-(4-pyridyl)ethanol

4-(2-chloro-1,1-diphenylethyl)pyridine

2-(4-methylphenyl)-1,1-diphenyl-1-(4-pyridyl)ethane

(diphenyl-4-pyridyl-methane)H[trans-RuCl₄(diphenyl-4-pyridyl-methane)]

Refernces

• 1、 Gao, Liuzhou,Wang, Guoqiang,Cao, Jia,Chen, Hui,Gu, Yuming,Liu, Xueting,Cheng, Xu,Ma, Jing,Li, Shuhua. "Lewis Acid-Catalyzed Selective Reductive Decarboxylative Pyridylation of N-Hydroxyphthalimide Esters: Synthesis of Congested Pyridine-Substituted Quaternary Carbons". . p. 10142 - 10151. Retrieved 2019/10/16.
• 2、 Lipp, Benjamin,Lipp, Alexander,Detert, Heiner,Opatz, Till. "Light-Induced Alkylation of (Hetero)aromatic Nitriles in a Transition-Metal-Free C-C-Bond Metathesis". . p. 2054 - 2057. Retrieved 2017/04/27.