2-Thiophenecarboxylic acid, 5-[1-ethyl-1-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]propyl]-

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-[1-ethyl-1-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]propyl]-
• CAS No.: 633339-25-0
• Molecular Formula: C₂₄H₃₄O₄S
• Molecular Weight: 418.598
• Mol file: 633339-25-0.mol

Synonyms:

Chemical Property of 2-Thiophenecarboxylic acid, 5-[1-ethyl-1-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-[1-ethyl-1-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]propyl]-

There total 2 articles about 2-Thiophenecarboxylic acid, 5-[1-ethyl-1-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3'-[4-(2-Hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-(thiophen-2-yl)pentane + carbon dioxide (124-38-9,18923-20-1) → 3'-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-[5-carboxy-thiophen-2-yl]pentane (633339-25-0,633339-29-4,633339-30-7)

Guidance literature:

3'-[4-(2-Hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-(thiophen-2-yl)pentane; With sec.-butyllithium; In diethyl ether; cyclohexane; at 0 - 20 ℃;

carbon dioxide; In diethyl ether; cyclohexane; at 20 ℃; for 2h;

With perchloric acid; water; sodium hydrogencarbonate; more than 3 stages;

Reference yield: 44.0%

C23H33LiO2S + carbon dioxide (124-38-9,18923-20-1) → 3'-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-[5-carboxy-thiophen-2-yl]pentane (633339-25-0,633339-29-4,633339-30-7)

Guidance literature:

In diethyl ether; cyclohexane; at 20 ℃; for 2h;

Reference yield: 51.0%

3'-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-[5-carboxy-thiophen-2-yl]pentane (633339-25-0,633339-29-4,633339-30-7) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → 3'-[4-(2-hydroxy-2,3,3-trimethylbutoxy)-3-methylphenyl]-3'-[5-(methylcarbonylmethylamino)carbonylthiophen-2-yl]pentane

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 72h;

upstream raw materials:

carbon dioxide

Refernces

• 1、 -. "PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS". Page 243. . Retrieved 2008/06/13.