(S)-2-Methyl-2-pyrrolidinecarboxylicacid

Base Information

• Chemical Name: (S)-2-Methyl-2-pyrrolidinecarboxylicacid
• CAS No.: 63399-73-5
• Molecular Formula: C6H11NO2.BrH
• Molecular Weight: 210.071
• Hs Code.: 2933990090
• Mol file: 63399-73-5.mol

Synonyms:2-methyl-L-proline hydrobromide;L-Proline,2-methyl-,hydrobromide;2S-methyl-pyrrolidine-2-carboxylic acid hydrobromide;

Chemical Property of (S)-2-Methyl-2-pyrrolidinecarboxylicacid

Chemical Property:

• PSA: 49.33000
• LogP: 0.54190

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-Methyl-2-pyrrolidinecarboxylicacid

There total 1 articles about (S)-2-Methyl-2-pyrrolidinecarboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2R,5S)-2-tert-butyl-5-methyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one (86046-11-9) → α-methyl-L-proline hydrobromide (63399-73-5)

Guidance literature:

With hydrogen bromide; for 8h; Ambient temperature;

DOI:10.1021/ja00354a034

Reference yield: 89.0%

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + α-methyl-L-proline hydrobromide (63399-73-5) → N-(tert-butoxycarbonyl)-2-methyl-L-proline (103336-06-7)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; Heating;

DOI:10.1021/jm00386a016

Reference yield: 64.0%

di-tert-butyl dicarbonate (24424-99-5) + α-methyl-L-proline hydrobromide (63399-73-5) → N-(tert-butoxycarbonyl)-2-methyl-L-proline (103336-06-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 5h;

upstream raw materials:

(2R,5S)-2-tert-butyl-5-methyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

Downstream raw materials:

N-(tert-butoxycarbonyl)-2-methyl-L-proline

(S)-1-((benzyloxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid

N-(tertbutyloxycarbonyl)-α-methyl-L-prolyl-L-phenylalanine

N-(tertbutyloxycarbonyl)-α-methyl-L-prolyl-L-phenylalanine methyl ester