1,2-Epoxytetradecane

Base Information

• Chemical Name: 1,2-Epoxytetradecane
• CAS No.: 3234-28-4
• Deprecated CAS: 130321-67-4
• Molecular Formula: C14H28 O
• Molecular Weight: 212.376
• Hs Code.: 2910900090
• European Community (EC) Number: 221-781-6
• DSSTox Substance ID: DTXSID9025249
• Nikkaji Number: J91.339A
• ChEMBL ID: CHEMBL1598368
• Mol file: 3234-28-4.mol

Synonyms:1,2-EPOXYTETRADECANE;3234-28-4;2-Dodecyloxirane;Oxirane, dodecyl-;Dodecyloxirane;1,2-Tetradecylene Oxide;Oxirane, 2-dodecyl-;CCRIS 2617;EINECS 221-781-6;AI3-14200;DTXSID9025249;EC 221-781-6;dodecyl oxirane;Oxirane, dodecyl;1-tetradecene oxide;2-Dodecyloxirane #;SCHEMBL284300;DTXCID705249;CHEMBL1598368;BCP30718;Tox21_200250;MFCD00037524;AKOS015855787;LS-1193;NCGC00091395-01;NCGC00091395-02;NCGC00257804-01;BP-26280;CAS-3234-28-4;1,2-Epoxytetradecane, technical grade, 85%;CS-0377964;E0314;FT-0606455;FT-0771748;W-109879

Chemical Property of 1,2-Epoxytetradecane

Chemical Property:

• Vapor Pressure: 0.00163mmHg at 25°C
• Melting Point: 185-186 °C (decomp)
• Refractive Index: 1.4408
• Boiling Point: 303.9°Cat760mmHg
• Flash Point: 99.3°C
• PSA: 12.53000
• Density: 0.86g/cm³
• LogP: 4.69620
• Water Solubility.: 130μg/L at 20℃
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 11
• Exact Mass: 212.214015512
• Heavy Atom Count: 15
• Complexity: 133

Purity/Quality:

98% ^*data from raw suppliers

1,2-Epoxytetradecane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCC1CO1
• Uses: 1,2-Epoxytetradecane is used in the preparation of polymeric prodrugs used in treatments of cancer.

Technology Process of 1,2-Epoxytetradecane

There total 14 articles about 1,2-Epoxytetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-tetradecene (1120-36-1) → 1,2-epoxytetradecane (3234-28-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 4 ℃; for 18h;

DOI:10.1039/b617942h

Reference yield: 93.0%

tetradecane-1,2-diol (21129-09-9) → 1,2-epoxytetradecane (3234-28-4)

Guidance literature:

tetradecane-1,2-diol; With hydrogen bromide; In acetic acid; for 0.5h;

With potassium carbonate; In methanol; for 2h;

DOI:10.1002/chem.200305670

Reference yield: 82.0%

myristylaldehyde (124-25-4,511542-15-7) → (R)-(+)-1,2-epoxytetradecane (3234-28-4,130321-67-4,130404-10-3,116619-64-8)

Guidance literature:

myristylaldehyde; With (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; In tetrahydrofuran; at 20 ℃;

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

With potassium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃;

DOI:10.3390/molecules24112081

upstream raw materials:

peracetic acid

1-tetradecene

tetradecane-1,2-diol

1-Bromotetradecane

Downstream raw materials:

n-Dodecyl-15-crown-5

2-dodecylcyclopropyl phenyl sulfone

2-Phenyltellanyl-tetradecan-1-ol

1-Phenyltellanyl-tetradecan-2-ol

Refernces

• 1、 Bourboula, Asimina,Limnios, Dimitris,Kokotou, Maroula G.,Mountanea, Olga G.,Kokotos, George. "Enantioselective organocatalysis-based synthesis of 3-hydroxy fatty acids and fatty γ-lactones". . . Retrieved 2019/06/10.
• 2、 Shin, Jong Won,Jeong, Ah Rim,Lee, Sun Young,Kim, Cheal,Hayami, Shinya,Min, Kil Sik. "Trinuclear nickel and cobalt complexes containing unsymmetrical tripodal tetradentate ligands: Syntheses, structural, magnetic, and catalytic properties". . p. 14089 - 14100. Retrieved 2016/11/06.