2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde

Base Information

• Chemical Name: 2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde
• CAS No.: 50634-05-4
• Molecular Formula: C7H12O4
• Molecular Weight: 160.17
• Hs Code.: 29321900
• European Community (EC) Number: 256-668-0
• DSSTox Substance ID: DTXSID20964872
• Nikkaji Number: J261.567C
• Mol file: 50634-05-4.mol

Synonyms:50634-05-4;2,5-DIMETHOXY-3-TETRAHYDROFURANCARBOXALDEHYDE;2,5-dimethoxyoxolane-3-carbaldehyde;2,5-dimethoxytetrahydrofuran-3-carbaldehyde;EINECS 256-668-0;3-formyl-2,5-dimethoxytetrahydrofuran;2,5-Dimethoxy-3-tetrahydrofurancarbaldehyde;Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde;2,5-dimethoxytetrahydro-3-furancarboxaldehyde;2,5-dimethoxy-tetrahydrofuran-3-carboxaldehyde;SCHEMBL272746;DTXSID20964872;STR03845;AKOS015912723;2,5-dimethoxytetrahydrofuran-3-aldehyde;2,5-dimethoxy-4-tetrahydrofurancarbaldehyde;2,5-dimethoxy-tetrahydrofuran-3-carbaldehyde;2,5-Dimethoxytetrahydro-3-furan carbaldehyde;CS-0237037;FT-0601899;2,5-dimethoxy-3-tetrahydrofuranecarboxaldehyde;2,5-Dimethoxytetrahydro-3-furancarbaldehyde #;2,5-dimethoxytetrahydrofuran-3-carboxaldehyde;2,5-dimethyoxy-3-tetrahydrofurancarboxaldehyde;2, 5-dimethoxytetrahydrofuran-3-carboxaldehyde;EN300-176899;3-Furancarboxaldehyde, tetrahydro-2,5-dimethoxy-;A828212;Furan-3-carboxaldehyde, 2,5-dimethoxy-tetrahydro-;J-640073;J-800075;Z1255402680

Chemical Property of 2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde

Chemical Property:

• Appearance/Colour: clear yellow to brown liquid
• Vapor Pressure: 0.232mmHg at 25°C
• Refractive Index: n20/D 1.4401(lit.)
• Boiling Point: 206.9 °C at 760 mmHg
• Flash Point: 91.6 °C
• PSA: 44.76000
• Density: 1.11 g/cm³
• LogP: 0.16680
• Storage Temp.: 2-8°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 160.07355886
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dimethoxytetrahydro-3-furancarboxaldehyde,TechnicalGrade ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CC(C(O1)OC)C=O
• Uses: 2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde was used in the synthesis of 9-(3-formylpyrrol-1-yl) ester by reacting with ethyl 9-amino-4,5-dihydro-4-oxo-1,2,4- triazolo[1,5-a]quinoxaline-2-carboxylate.

Technology Process of 2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde

There total 2 articles about 2,5-Dimethoxy-3-tetrahydrofurancarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dihydro-2,5-dimethoxyfuran (332-77-4) + carbon monoxide (201230-82-2) → 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde (50634-05-4,159551-27-6,159551-33-4,159551-28-7,159551-29-8,159551-30-1,159551-34-5)

Guidance literature:

With hydrogen; carbonylhydridetris(triphenylphosphine)rhodium(I); In benzene; at 60 ℃; for 0.5h; under 45600 Torr; Product distribution; variation of pressure, temperature, time;

DOI:10.1007/BF01168088

Reference yield:

→ 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde (50634-05-4,159551-27-6,159551-33-4,159551-28-7,159551-29-8,159551-30-1,159551-34-5)

Guidance literature:

Aus (1), CO/H2/Rh;

Reference yield: 100.0%

2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde (50634-05-4,159551-27-6,159551-33-4,159551-28-7,159551-29-8,159551-30-1,159551-34-5) + benzylamine (100-46-9) → 1-benzyl-1H-pyrrole-3-carbaldehyde (30186-48-2)

Guidance literature:

With acetic acid; at 90 ℃; for 12h;

DOI:10.1016/j.ejmech.2015.08.044

upstream raw materials:

2,5-dihydro-2,5-dimethoxyfuran

carbon monoxide

Downstream raw materials:

diethyl N-<4-(3-formyl-1-pyrrolyl)benzoyl>-L-glutamate

1-(4-methylphenyl)-3-formyl-1H-pyrrole

1-(2,5-Dimethoxy-tetrahydro-furan-3-yl)-3-phenyl-prop-2-yn-1-ol

1-phenyl-1H-pyrrole-3-carbaldehyde

Refernces