Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-

Base Information

• Chemical Name: Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-
• CAS No.: 63472-21-9
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Mol file: 63472-21-9.mol

Synonyms:3-biphenyl-4-yloxy-propionic acid;3-Biphenyl-4-yloxy-propionsaeure;p-Biphenyl-propionsaeure-aether;

Chemical Property of Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-

Chemical Property:

• PSA: 46.53000
• LogP: 3.20710

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Phenylphenoxy)propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-

There total 8 articles about Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(4-phenylphenoxy)-1-propanol (173025-78-0) → 3-([1,1'-biphenyl]-4-yloxy)propanoic acid (63472-21-9)

Guidance literature:

With Jones reagent; In acetone; at 0 ℃; for 1h;

DOI:10.1039/c4ob00649f

Reference yield:

3-(biphenyl-4-yloxy)-propionyl chloride → 4-Phenylphenol (92-69-3) + 3-([1,1'-biphenyl]-4-yloxy)propanoic acid (63472-21-9) + 3-(4-phenylphenoxy)propanohydroxamic acid

Guidance literature:

With 4-methyl-morpholine; hydroxylamine hydrochloride; In tetrahydrofuran; water; for 2.5h;

DOI:10.1021/ja9702778

Reference yield:

3-(2,4-dichlorophenoxy)propionic acid (3284-80-8) → 6,8-dichloro-2,3-dihydrochromen-4-one (49660-60-8) + 3-([1,1'-biphenyl]-4-yloxy)propanoic acid (63472-21-9)

Guidance literature:

With phosphorus pentaoxide; In methanesulfonic acid;

upstream raw materials:

β-Propiolactone

4-Phenylphenol

3-(biphenyl-4-yloxy)-propionitrile

3-(4-phenylphenoxy)-1-propanol

Downstream raw materials:

2-(biphenyl-4-yloxy)acetyl chloride

4-phenylphenoxyacetic acid

4-Phenylphenol

6-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

Refernces

• 1、 Liu, Yajun,Park, Se Kyung,Xiao, Yan,Chae, Junghyun. "Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers". supporting information. p. 4747 - 4753. Retrieved 2014/06/24.
• 2、 -. "Biphenyl hydroxamate inhibitors of matrix metalloproteinases". . . Retrieved 2008/06/13.